1. The major pathological responses to Gram-negative bacterial sepsis are triggered by endotoxin or lipopolysaccharide. As endotoxin is shed from the bacterial outer membrane, it induces immunological responses that lead to release of a variety of cytokines and other cellular mediators. As part of a program aimed at developing a therapeutic agent for septic shock, we have developed E5531, a nov...

BACKGROUND Spontaneous bacterial peritonitis (SBP) is a severe and often fatal infection in patients with cirrhosis and ascites. AIM To review the known and changing bacteriology, risk factors, ascitic fluid interpretation, steps in performing paracentesis, treatment, prophylaxis and evolving perspectives related to SBP. METHODS Information was obtained from reviewing medical literature acc...

Background and Objective: Pseudomonas aeruginosa is an opportunistic bacterium and is one of the main causes of infection in burn patients. As this bacterium gets resistant to various types of antibiotics through different acquiring mechanisms, it can easily result in skin deformities and even patients’ death. Methods: This descriptive study was carried o...

abstract       background and objective: the spread of drug resistance in bacteria have prompted researchers to seek suitable alternative for antimicrobial drugs among various medicinal plants and nanoparticles. the aim of this study was to evaluate the effect of silver nanoparticles alone and in combination with methanol extract of zataria multiflora on five gram-positive and gram-negative bac...

The effectiveness of aminopterin and Amethopterin in those cases of acute leukemia in children which respond to these agents appears to be nullified eventually by the development of drug resistance (28). The metabolic characteristics which enable the resistant leukemic cell to cir cumvent the effect of the drug are not clearly understood. Direct comparison of antagonistsensitive and -resistant ...

rosemary (rosmarinus officinalis) is a common household plant grows in many parts of the world, including iran. rosemary leaves are used in folk medicine as an antispasmodic, analgesic, diuretic and ntiepileptic agent. the objective of this study was to investigate the antinociceptive mechanisms of rosemary extract using a writhing test as a model of visceral pain. possible antinociceptive mech...

the effects of cholecystokinin (cck) receptor antagonists on hypothermia induced by cocaine or morphine have been studied in mice. in the present work, subcutaneous (sc) injection of cocaine (50-150 mg/kg) or morphine (125-500 mg/kg) induced hypothermia in mice. administration of ccka receptor antagonist mk-329 (0.5-1.5 mg/kg), cckb receptor antagonist l-365, 260 (0.5-1.5 mgl kg) and cck recept...

UNLABELLED The ileal lesions of Crohn's disease (CD) patients are colonized by adherent-invasive Escherichia coli (AIEC) bacteria. These bacteria adhere to mannose residues expressed by CEACAM6 on host cells in a type 1 pilus-dependent manner. In this study, we investigated different antagonists of FimH, the adhesin of type 1 pili, for their ability to block AIEC adhesion to intestinal epitheli...

Background: Male factors, mainly spermatogenesis disorder, are responsible for 20-30% of infertility occurs in different societies. One of the known causes of spermatogenesis disorder is chemotherapy in patients with cancer. The side effect of chemotherapic agents may last from 10 years up to the end of the life. Since dividing cells are mainly affected by anticancer drugs, the aim of the prese...

Background: Ovarian hyperstimulation syndrome is the most serious complication of ovarian stimulation. This novel study aimed to describe an outpatient treatment protocol for ovarian hyperstimulation syndrome (OHSS) that results in rapid normalization of symptoms with minimal side effects. Materials and Methods: A prospective study was undertaken at Infertility department of Shariati Hospital a...