background: ghrelin is a hormone related to food intake in rodents and humans, mainly produced in stomach. this study aimed to determine the effect of irradiation on ghrelin concentration in the gastric mucosa of rats. materials and methods : twenty-five rats were exposed to 15 gy of whole-abdominal irradiation. gastric tissue samples were obtained 1, 3, 7, 30, and 90 days after irradiation. fi...

BACKGROUND No epidemiologic survey examining eating disorders in Japan has been done at a national level since 1992. The prevalence of anorexia nervosa, as assessed by questionnaires to hospitals, is thought to be underestimated because patients with anorexia nervosa tend to avoid consultations. In conformity with the School Health and Safety Act of Japan, schools are required to have physician...

Anorexia nervosa presenting as Wernicke-Korsakoff syndrome is rare. The causes of Wernicke-Korsakoff syndrome are multiple like alcohol abuse, thyrotoxicosis, haemodialysis, severe malnutrition because of gastric carcinoma and pyloric obstruction, hyperemesis gravidarum, and prolonged parenteral feeding. We report a case of anorexia nervosa, who presented with Wernicke's encephalopathy and prog...

Beginning in the 1980s, the number of patients with anorexia nervosa has increased dramatically in Japan. Afterwards, the estimated prevalence in Japanese hospitals increased approximately five times over about 20 years. Recently, the national center initiative and the Japanese guideline for eating disorder have been launched. In this article, the author specifically reviewed early history in m...

OBJECTIVE We analyze 27 point-prevalent DSM-IV Axis I comorbidities for eating disorder inpatients. METHODS The sample included 2436 female inpatients treated between January 1, 1995, and December 31, 2000, for primary DSM-IV diagnoses of anorexia, bulimia, and eating disorder not otherwise specified. Analyses were multivariate analysis of variance and multinomial logistic regression; sociode...

Anorexia nervosa is a severe psychiatric disorder most commonly starting during the teenage-years and associated with food refusal and low body weight. Typically there is a loss of menses, intense fear of gaining weight, and an often delusional quality of altered body perception. Anorexia nervosa is also associated with a pattern of high cognitive rigidity, which may contribute to treatment res...