Non-protein-coding DNA comprises the majority of animal genomes but its functions are largely unknown. We identified over 17,000 different tetranucleotide pairs in the Drosophila melanogaster genome that are over-represented at distances up to 100nt in conserved non-exonic sequences. Those exhibiting the highest information content in surrounding nucleotides were classified into five groups: tR...

BACKGROUND Pathological stresses induce heart failure in animal models through activation of multiple cardiac transcription factors (TFs) working cooperatively. However, interactions among TFs in human heart failure are less understood. Here, we use genomic data to examine the evidence that 5 candidate TF families coregulate gene expression in human heart failure. METHODS AND RESULTS RNA isol...

Despite enormous body plan variation, genes regulating embryonic development are highly conserved. Here, we probe the mechanisms that predispose ancient regulatory genes to reutilization and diversification rather than evolutionary loss. The Hox gene fushi tarazu (ftz) arose as a homeotic gene but functions as a pair-rule segmentation gene in Drosophila. ftz shows extensive variation in express...

Epilepsy is a chronic neurological disorder that has affected around 50-70 million people worldwide. Various animal models have previously been used in epilepsy research. To expand the knowledge of disease, new model suggested to be explored considering genetic and phenotypic heterogeneity contributes complexity disease. This study was undertaken analyze 14 causative genes disease Japanese meda...

application of human figures on brocades is valuable for studying. the existence of these motifs on the bouid’s & saljuk’s brocades indicates the popularity of them at this era in persia. these are very important sources for studying the weaving techniques. the production of silk fabrics made a magnificent period for persian textile industry. in this research work samples of fabrics with human ...