A study was conducted to determine whether the covalent chemical modification of Brucella abortus 19 salt-extractable proteins (BCSP) and BCSP derivatives would modulate the immune responses in BALB/c mice. Salt-extractable proteins BCSP 0-70 and BCSP 70-100 were modified with acetoacetic anhydride, and recombinant proteins rBCSP20 (20 kDa), rBCSP31 (31 kDa), and rBCSP45 (45 kDa) were modified ...

We investigated the effects of antidepressants on the gene expression profile and behavior of olfactory-bulbectomized (OBX) rats. Removal of the main olfactory bulbs in rats alters neuronal function in brain areas involved in emotional regulation, resulting in maladaptive behavioral patterns similar to the symptoms of patients with depression. Previously, we found that OBX-induced behavioral an...

The present study describes an economic and scalable approach to aqueous mesophases from bola-amphiphiles (BA) obtained via nucleophilic addition of dimer fatty acid based α,ω-polyesterdiols (PES) on cyclic acid anhydrides and conversion of the carboxylic end groups into ammonium salts. Novel bola-amphiphilic head groups are introduced using alkenyl succinic anhydrides (ASA). The additional ter...

Terfenadine reacts with mixed anhydrides (malonic and acetic anhydrides) producing a yellow-coloured product with intense fluorescence. Based on this fact, a spectrophotometric method was developed for the determination of terfenadine in dosage forms. The relation between the absorbance at 395 nm and the concentration is rectilinear over the range 0.5-5 microg ml(-1) (molar absorptivity is 1.40...

An improvement of the efficiency of organic chemical synthesis was attempted by the imitation of natural reactions. Phosphorylated amino acid derivatives and the rupture of thus obtained »high energy phosphates« was used for aminoacylations of 6-11minopenicillanic acid (6-APA). Namely, the energy-rich mixed anhydrides, formed from adenosine triphosphate (ATP) and amino acids were shown to be th...

The difructose anhydrides include four welldefined crystalline sugars. Diheterolevulosan was first prepared by Pictet and Chavan [1]l by the action of concentrated hydrochloric acid on fructose at 0° C. This sugar is a difructopyranose in which carbon atoms 1 and 2 of each fructose residue are joined to form a dioxane ring. The other members [2,3] of this group arc designated difructose anhydri...