We have investigated the effects of cilostazol, a type III phosphodiesterase inhibitor, on the electrical responses of smooth muscle tissue isolated from the guinea-pig stomach antrum. Cilostazol (10(-5) M) inhibited slow waves recorded from circular muscle cells, but did not significantly alter the pacemaker potentials and follower potentials recorded from myenteric interstitial cells and long...

introduction: the teratogenic effect of caffeine depends on the dosage and the route of administration. a daily oral dose of caffeine (80 mg/kg) is tetrogenic for rat. in present study, the teratogenic effects of caffeine on the development of bones and the resoption of skeletal cartilage in the rat embryo were quantitatively evaluation. materials and methods: three groups of pregnant rats were...

Two hundred twenty-eight surveyed parents reported that their 5 to 7 year old children drank approximately 52 mg of caffeine daily and their 8 to 12 year old children drank 109 mg daily. Caffeine consumption and hours slept were significantly negatively correlated, but caffeine consumption and enuresis were not significantly correlated. Spanish-speaking parents reported fewer bedwetting events ...

AIMS We investigated whether the treatment with anthocyanins prevents the scopolamine-induced memory deficits and whether ectonucleotidase activities and purine levels are altered in the cerebral cortex (CC) and hippocampus (HC) in this model of mnemonic deficit in rats. MAIN METHODS The animals were divided into 4 experimental groups: control (vehicle), anthocyanins (Antho), scopolamine (SCO...

Development of an environmental friendly and cost-effective process for microbial degradation of caffeine to non-toxic compounds are promising to solve the problems of physiochemical extraction of caffeine in the treatment the caffeine containing agro-industrial effluents. Thirteen bacterial strains, isolated from tea plantation soils in the north region of Iran, were screened to show their abi...

Biological uranium reduction was investigated using bacteria isolated from a uranium mine in Limpopo, South Africa. Background uranium concentration in soil from the mine was determined to be 168 mgkg(-1) much higher than the typical background uranium concentration in natural soils (0.30-11.7 mgkg(-1)). Therefore it was expected that the bacteria isolated from the site were resistant to U(VI) ...

STUDY OBJECTIVE To evaluate the efficacy and safety of caffeine citrate for treatment of apnea of prematurity. DESIGN Multicenter, parallel, randomized, double-blind, placebo-controlled trial with open-label rescue. SETTING Nine neonatal intensive care units. PATIENTS Eighty-five infants, 28-32 weeks postconception and 24 hours or more after birth who had six or more apnea episodes within...

Caffeine has been much used to examine the possibility that ryanodine receptors similar to those found in skeletal and cardiac muscle may be more widely distributed and perhaps contribute to regenerative Ca2+ signals in electrically inexcitable cells. In permeabilized hepatocytes loaded with 45Ca2+, caffeine (> or = 5 mM) decreased the 45Ca2+ content of the intracellular stores by up to 60%; th...

We have recently shown that Alzheimer's disease (AD) transgenic mice given a moderate level of caffeine intake (the human equivalent of 5 cups of coffee per day) are protected from development of otherwise certain cognitive impairment and have decreased hippocampal amyloid-beta (Abeta) levels due to suppression of both beta-secretase (BACE1) and presenilin 1 (PS1)/gamma-secretase expression. To...

Sleep spindles and spike-wave discharges are thought to originate from the same thalamic pacemaker. In the present work it is investigated whether sleep spindles and spike-wave discharges are also sensitive for the same drugs. Adult male WAGIRij rats were chronically implanted with frontal and occipital EEG electrode pairs. Rats were intraperitoneally injected with clonidine (0.00625 mgkg), phe...