Polymerase chain reaction amplification and DNA sequencing of the Toxoplasma gondii dihydropteroate synthase gene (dhps) identified 4 alleles among parasite populations from 32 cases of human toxoplasmosis. Heterologous expression and enzyme assay reveal that 3 of these alleles encode sulfadiazine (Sdz)-sensitive enzymes. The fourth, generating a highly Sdz-resistant enzyme, differs from 1 of t...

Frizzled receptors in Drosophila. Science 288, 1825–1828 12 Willnow, T.E. et al. (1999) Lipoprotein receptors: new roles for ancient proteins. Nat. Cell Biol. 1, E157–E162 13 Trommsdorff, M. et al. (1999) Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Cell 97, 689–701 14 Wehrli, M. et al. (2000) arrow encodes an LDL-receptor...

Abstract We present time resolved low resolution spectra of BLAP-009 and BLAP-014 collected with SPRAT on the Liverpool Telescope. The were median-stacked in four ranges phase. It was intended to note variation shape helium absorption lines as a function phase, but they do not appear vary spectra. lack clear offsets suggest that there can only be small radial velocity due either unseen companio...

S/s 0102-LF-014-6603 SECUR I TY CLASS I F ICAT ION OF TH I S PAGE A Really Temporal Logi&” Rajeev Alur Thomas A. Henzinger Depa.rtment of Computer Science Stanford University

The present study investigates the effect of crystalline and amorphous carriers for the improvement of dissolution profile of broad spectrum antifungal agent Itraconazole. A comparative study was performed to estimate the ability of Poloxamer-407 (crystalline carrier) and modified Gum Karaya (amorphous carries) for enhancing the dissolution profile of Itraconazole (BCS class II). Solid dispersi...