The population pharmacokinetics on tazobactam/piperacillin (TAZ/PIPC; 1:8, 4.5 g x 3) was analyzed in Japanese patients with community-acquired pneumonia using the Nonlinear Mixed Effect Model version VI. Analysis by the one-compartment model yielded the following results for PIPC: total clearance (CL) = 8.22+(Ccr-71.4) x 0.0561 (L/hr), distribution volume (Vd) = 13.7 (L). The pharmacokinetic p...

Serum concentrations of fazadinium were measured in eight patients with cirrhosis and eight patients with total biliary obstruction who underwent abdominal surgery. A biexponential decay of the concentration was observed after a single i.v. injection of fazadinium. A two-compartment open model was used in the pharmacokinetic analysis of the data. The pharmacokinetic parameters were compared wit...

BACKGROUND It is common clinical practice to administer reduced doses of opioid to patients suffering from hemorrhagic shock to minimize adverse hemodynamic consequences and to prevent prolonged opioid effect However, the scientific foundation supporting this practice is not well established. The aim of this study was to test the hypothesis that hemorrhagic shock alters both the distribution an...

We predict that vertical transport in heterostructures formed by twisted graphene layers can exhibit a unique bistability mechanism. Intrinsically bistable I -V characteristics arise from resonant tunneling and interlayer charge coupling, enabling multiple stable states in the sequential tunneling regime. We consider a simple trilayer architecture, with the outer layers acting as the source and...

OBJECTIVES The World Health Organization recommends that all children admitted with severe malnutrition should routinely receive parenteral ampicillin and gentamicin; despite this, mortality remains high. Since this population group is at risk of altered volume of distribution, we aimed to study the population pharmacokinetics of once daily gentamicin (7.5 mg/kg) in children with severe malnutr...

Controlling weight gain is an important factor when applying any coating, but it becomes absolutely critical when the coating contains an API. This article presents a case study that identifies the critical process parameters for developing a consistent and robust coating process that provides in-range results. low-dose drug products, although manufacturing highdose products is simpler because ...

BACKGROUND Distal radius fracture is the most common fracture of the upper extremity, and approximately 60,000 distal radius fractures occur annually in Korea. Internal fixation with an anatomical volar locking plate is widely used in the treatment of unstable distal radius fractures. However, most of the currently used distal radius anatomical plate systems were designed based on the anatomica...

BACKGROUND Anterior cruciate ligament (ACL) loading during drop landing has been recently studied with a sagittal plane knee model developed by Kernozek and Ragan using mean anatomical and physiological parameters obtained from cadaveric and clinical data. It is unknown how estimates in ACL load may be altered due to variations in anatomical and physiological parameters used from other research...

urtica dioica l. is an iranian native pharmacological plant for which little attention has been paid to the anatomical structure. medical applications of this plant include diabetes therapy, digestive improvement, anemia and kidney disease therapy. because climatic conditions can affect the anatomical structure which in turn affects pharmacological compositions, research on the anatomy of this ...

case presentation a 30-year-old male patient with a history of severe, throbbing, constant pain in the lower mandibular molars was referred to the department of endodontics of hamedan dental university. the patient’s medical history was noncontributory. the buccal object rule (same-lingual opposite-buccal technique) confirmed the additional root as a distolingual root (radix entomolaris). follo...