Growth hormone when used in precocious puberty in combination with Gonadotropin releasing hormone analogue (GnRHa) instead of using GnRHa alone has been shown to improve final height prognosis. We report here a two-year follow-up of three cases of precocious puberty, two of whom were treated with a combination of GH and GnRHa and the third treated with GnRHa alone.

Intraarterial injection may result in acute ischemia and amputation. The authors describe the case of a 27-year-old man with an acute hand ischemia following intraarterial injection of a suspension of buprenorphine. Despite its initial severity, this case was successfully treated with iloprost, a stable prostacyclin analogue, and dextran-40, a low-molecular-weight dextran.

Cypermethrin is a synthetic pyrethroid and pyrimethrin analogue. Cypermethrin poisoning produces neurological manifestations due to its primary target on sodium channels.1 Neuropathy following cypermethrin poisoning is common. But myelopathy is rare and not reported so far. We report a 17 year old healthy male who developed myelopathy following cypermethrin ingestion. The possible mechanism for...

D igital computers and mammalian brains share not only a talent for computation but also a method that favors absolutes. The ones and zeros of a computer are analogous to the all-or-none character of action potentials in the brain. Neurons sum all incoming depolarizing signals until, at a threshold level of depolarization, an action potential fi res along the axon. Now, however, Henrik Alle and...

Evolution-in-materio (EIM) is the manipulation of a physical system by computer controlled evolution (CCE). It takes the position that to obtain useful functions from a physical system one needs to apply highly specific physical signals and place the system in a particular physical state. It argues that CCE is an effective methodology for doing this. One of the potential advantages of this is t...