BACKGROUND Mediastinitis resulting from surgical site infection may occur in 1% of patients undergoing median sternotomy. METHODS Case report and review of the pertinent English-language literature. RESULTS We report a case of mediastinitis caused by Acinetobacter baumannii, in a patient with multiple comorbidities who underwent cardiopulmonary bypass. Successful treatment consisted of surg...

We evaluated several 3-day antimicrobial regimens in the treatment of experimental endocarditis caused by an oxacillin-resistant Staphylococcus aureus strain exhibiting intermediate susceptibility in vitro to vancomycin (VISA). Neither vancomycin alone nor trovafloxacin exhibited in vivo efficacy; addition of amikacin to vancomycin yielded a modest in vivo effect. In contrast, the combination o...

We previously observed marked synergy between daptomycin and both rifampin and ampicillin against vancomycin-resistant enterococci (VRE). Because the synergy between daptomycin and ampicillin was observed for 100% of VRE strains with high-level ampicillin resistance (ampicillin MIC of > or =128 microg/ml), we looked for synergy between daptomycin and other beta-lactams against 18 strains of met...

We previously observed marked synergy between daptomycin and both rifampin and ampicillin against vancomycin-resistant enterococci (VRE). Because the synergy between daptomycin and ampicillin was observed for 100% of VRE strains with high-level ampicillin resistance (ampicillin MIC of >128 g/ml), we looked for synergy between daptomycin and other -lactams against 18 strains of methicillin-resis...

The antimicrobial susceptibility of the pathogens is essential for successful treatment bovine mastitis. Antimicrobial resistance develops in microbes as a result indiscriminate use antibiotics. Therefore, regular screening required selection appropriate and effective antimicrobials. A study was carried out 60 crossbred dairy cows early lactation with objective to assess morphological character...