Y. Janssen, 2, ∗ M. Angst, K. W. Dennis, P. C. Canfield, 3 and R. W. McCallum 4 Condensed Matter Physics, Ames Laboratory, Ames, Iowa 50011, USA Materials and Engineering Physics, Ames Laboratory, Ames, Iowa 50011, USA Department of Physics and Astronomy, Iowa State University, Ames, Iowa 50011, USA Department of Materials Science and Enigineering, Iowa State University, Ames, Iowa 50011, USA (...

LANGOVÁ M., POLÍVKOVÁ Z., ŠMERÁK P., BÁRTOVÁ J., BÁRTA I. (2005): Antimutagenic effect of resveratrol. Czech J. Food Sci., 23: 202–208. Evidence exist from population-based and laboratory studies that some phytochemicals have protective effects against tumors or other diseases and reveal antimutagenic activity. We studied the protective effect of the plant phytoallexin resveratrol on the mutage...

The aim of this study was to assess the interaction of a series of well characterised nano-objects with the Gram negative bacterium Salmonella typhimurium, and how such an interaction may relate to the potential mutagenicity of nano-objects. Transmission electron microscopy showed that nano-objects (Au-PMA-ATTO NPs, CeO₂ NPs, SWCNTs and MWCNTs), as well as CAFs entered S. typhimurium. Only DEPs...

In our previous paper we examined mutagenic and genotoxic activity of 4 α-asarone isomers 2-5 exhibiting relatively high hypolipidemic activity. In the present paper, we examined genotoxic activity of αasarone and its isomers as the ability to damage cellular DNA, evaluated in the comet assay. Additionally, mutagenic activity of α-asarone in Ames test has been examined. The Ames test for α-asar...

Perfluorooctanoic acid (PFOA) is a perfluorinated compound ubiquitously detected in the environment, including wildlife and humans. Despite the available information, research on the cytotoxicity of PFOA in non-tumoral mammalian cells is relatively limited. In this work, two in vitro toxicity systems were employed to provide further insight into the cytotoxic and mutagenic potential of PFOA. Th...

An investigation was undertaken to determine whether analgesics and their derivatives (13 compounds), and anti-inflammatory drugs (4 compounds) had mutagenicity. Rec-assay was used to clarify specific DNA-damaging properties, and the Ames test was used to find back-mutations, using S-9 fractions obtained from the liver of 4 animal species pretreated with polychlorobiphenyl. In the Rec-assay, sa...

R.M. Haberle, NASA/Ames Research Center ([email protected]), J.L Hollingsworth, NASA/Ames Research Center ([email protected]), A. Colaprete, NASA/Ames Research Center ([email protected]) A.F.C. Bridger, San Jose State University ([email protected]), C.P. McKay, NASA/Ames Research Center ([email protected]), J.R. Murphy, New Mexico State University (mur...