Amegakaryocytic thrombocytopenic purpura (AMTP), first reported by Korn,1 is a rare disease characterized by severe thrombocytopenia associated with a total absence or a selective decrease in bone marrow megakaryocytes. Previous studies suggest a variety of pathogenetic mechanisms for AMTP, such as the intrinsic defect at the megakaryocyte progenitor cell level and humoral and cellular suppress...

Background: A fault in chromosome distribution during cell division leads to aneuploidy, which can be associated with thrombocytopenia. Various hematological abnormalities have been reported among neonates with Down syndrome (DS). Neutrophilia, thrombocytopenia and polycythemia were the most common hematological abnormalities observed among neonates with Down syndrome. In particular, thrombocyt...

Background: Determining the prevalence and risk factors of thrombocytopenia among neonates enables us to prevent the inevitable and sometimes irreversible complications. In this study we aimed to survey the frequency of thrombocytopenia and its demographic features and risk factors. Materials and methods: In this cross sectional study the platelet counts of 364 neonates admitted to neonatal ...

objectives the aim was to study the prevalence of thrombocytopenia in hcv patients without cirrhosis and splenomegaly. patients and methods a cross-sectional study was carried out in the gastrointestinal out patient department (g.i. opd) of the sindh institute of urology and transplantation (siut) from september-november 2013. 30 patients aged between 18 - 60 years with a positive anti-hcv resu...

typhoid fever is a common infection in children in developing countries. typhoid fever is a systemic illness which affects many organs. isolated hepatitis, thrombocytopenia and acute renal failure complicating typhoid fever are well known. the potential of multiorgan involvement in typhoid fever - on rare occasions - may occur simultaneously in the same patient.

abstract background brucella mellitensis, the most invasive strain of brucella, is the predominant strain of genus brucella in iran. it causes variety of hematological abnormalities some of which are frequent and causes difficulties in diagnosis. objective to find hematological abnormalities of brucellosis in hospitalized patients in an endemic area. materials and methods a retrospective review...

sunitinib is an oral tyrosine kinase inhibitor which prevents tumor growth and metastatic progression. it was approved for treatment of advanced renal cell cancer, gastrointestinal stromal tumor and advanced pancreatic neuroendocrine tumors. it has several adverse reactions on multi organ systems including hematologic system. although the neutropenia and thrombocytopenia commonly happens as gra...

background: determining the prevalence and risk factors of thrombocytopenia among neonates enables us to prevent the inevitable and sometimes irreversible complications. in this study we aimed to survey the frequency of thrombocytopenia and its demographic features and risk factors. materials and methods: in this cross sectional study the platelet counts of 364 neonates admitted to neonatal int...

conclusions our results suggest that liver cirrhosis does not cause impaired thrombopoietin production even in the late stage of disease. thrombopoietin has no contribution for the occurrence of thrombocytopenia in cirrhosis; splenic sequestration seems to be the main factor. results platelet counts were lower in patients with cirrhosis (97000 ± 8000/mm3) than in healthy subjects (240000 ± 5100...