New treatment options may lead to an increased interest in using reliable and sensitive instruments assess health-related quality of life people with alopecia areata (AA). The purpose this paper is present current knowledge about assessment AA. dermatology-specific Dermatology Life Quality Index (DLQI) was the most widely reported instrument used Three AA-specific (Alopecia Areata Symptom Impac...

background: alopecia areata (aa) is a non-scarring, autoimmune disorder which causes hair loss. inflammatory reactions are involved in hair loss of the scalp and/or body. the involvement of chemokine receptors in the pathogenesis of aa is well defined among which, cxcl1 acts on neutrophils and cxcl9, cxcl10 and cxcl12 and serve as t lymphocytes recruiters. objective: to study the serum levels o...

Th1/Th2 peripheral blood balance and CD200 expression in patients with severe alopecia areata (SAA) in the active stage were investigated. Fifty patients with active SAA, 50 patients with stable SAA and 50 healthy controls were continuously selected and expression of Th1/Th2 of peripheral T lymphocytes, and peripheral B lymphocytes was detected by flow cytometry; RT-PCR was used to detect the e...

Alopecia areata is an autoimmune disease characterized by non-scaring hair loss. The onset in over 50-year-old patients is rare and has barely been studied. Cases of this disease have been retrospectively analyzed - according to clinical forms, extension, and associated diseases - to assess alopecia areata characteristics in a group of patients whose disease onset was after the age of 50. 30 pa...

BACKGROUND Alopecia can be a manifestation of mycosis fungoides (MF); however, the prevalence is unknown. AIMS We sought to describe the clinicopathologic presentation of alopecia in patients with diagnosis of MF. METHODS A retrospective analysis of patients with biopsy-proven MF, who were evaluated at our cancer center from 2002 to 2012, was performed to identify patients with alopecia. ...

A young adult male patient presented with diffuse hair loss of two years duration. Clinical features and investigations were suggestive of loose anagen hair syndrome. He developed alopecia totalis during follow-up. Scalp biopsy revealed perifollicular lymphocytic infiltration. A diagnosis of adult-onset loose anagen hair syndrome with alopecia areata was made. Introduction Loose anagen hair syn...

Tyrosine kinase enzymes are an attractive target for anticancer therapies. Tyrosine kinase inhibitors (TKI) are well tolerated; somehow severe systemic side effects are rarely seen during treatment. Toxicities of skin and appendages may lead to poor compliance, psychosocial inconvenience, and drug interruption. Changes of the hair can arise following cures with TKI. Nilotinib, a second-generati...