نتایج جستجو برای: allylic alcohols

تعداد نتایج: 13311  

Journal: :Angewandte Chemie 2017
Manuel van Gemmeren Marino Börjesson Andreu Tortajada Shang-Zheng Sun Keisho Okura Ruben Martin

A switchable site-selective catalytic carboxylation of allylic alcohols has been developed in which CO2 is used with dual roles, both facilitating C-OH cleavage and as a C1 source. This protocol is characterized by its mild reaction conditions, absence of stoichiometric amounts of organometallic reagents, broad scope, and exquisite regiodivergency which can be modulated by the type of ligand em...

Journal: :Organic & biomolecular chemistry 2006
Shankar D Markad Narayan S Karanjule Tarun Sharma Sushma G Sabharwal Dilip D Dhavale

The Johnson-Claisen rearrangement of D-gluco and L-ido-derived allylic orthoesters afforded gamma,delta-unsaturated ester that on ester reduction, epoxidation, regioselective oxirane opening by sodium azide and hydrogenation led to sugar amino alcohols--immediate precursors for 1-deoxy-homonojirimycin 3a,b, and polyhydroxylated homoazepanes 4a,b. Our synthetic approach and glycosidase inhibitor...

2015
Graeme Barker David G Johnson Paul C Young Stuart A Macgregor Ai-Lan Lee

Gold(I)-catalysed direct allylic etherifications have been successfully carried out with chirality transfer to yield enantioenriched, γ-substituted secondary allylic ethers. Our investigations include a full substrate-scope screen to ascertain substituent effects on the regioselectivity, stereoselectivity and efficiency of chirality transfer, as well as control experiments to elucidate the mech...

Journal: :Current drug metabolism 2000
E Banoglu

Cytosolic sulfotransferases (SULT) catalyze the sulfation of structurally diverse drugs, endogenous compounds and xenobiotics. These reactions involve the transfer of a sulfuryl group from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the hydroxyl/amino groups of acceptor molecules. Although sulfate conjugation is generally considered as a detoxication pathway producing more water-soluble and...

Journal: :Chemical communications 2013
Narendar Reddy Gade V Devendram Manojit Pal Javed Iqbal

IBX facilitated the reaction of β-enamino esters with allylic alcohols affording a direct, one-pot and metal free synthesis of functionalized pyridines including 2-substituted nicotinic acids, densely substituted pyridines and precursors of azafluorenones. The methodology also afforded the racemic pyridine core of cyclothiazomycin.

Journal: :Chemical communications 2013
John M Ketcham Berenger Biannic Aaron Aponick

The Au(I)-catalyzed intermolecular hydroalkoxylation of alkynes with allylic alcohols to provide allyl vinyl ethers that subsequently undergo Claisen rearrangement is reported. This new cascade reaction strategy facilitates the direct formation of γ,δ-unsaturated ketones from simple starting materials in a single step.

Journal: :Chemical communications 2014
B H Lipshutz M Hageman J C Fennewald R Linstadt E Slack K Voigtritter

Allylic and benzylic alcohols can be selectively oxidized to their corresponding aldehydes or ketones in water containing nanoreactors composed of the designer surfactant TPGS-750-M. The oxidation relies on catalytic amounts of CuBr, bpy, and TEMPO, with N-methyl-imidazole; air is the stoichiometric oxidant.

Journal: :Organic letters 2016
Zhiyuan Huang Qingquan Lu Yichang Liu Dong Liu Jian Zhang Aiwen Lei

A highly regio- and stereoselective oxysulfonylation of allenes was developed that provided direct access to 2-sulfonyl allylic alcohols in good yields. By means of dioxygen activation, selective difunctionlization of allenes could be successfully achieved under mild metal-free conditions. Preliminary mechanistic investigation disclosed that this transformation probably goes through a radical p...

Journal: :Organic & biomolecular chemistry 2015
Haibo Peng Jin-Tao Yu Yan Jiang Jiang Cheng

A copper-catalyzed radical 1,2-aryl migration in α,α-diaryl allylic alcohols is developed, leading to β-silyl carbonyl compounds in moderate to good yields. The migration of aryls with lower aromaticity is favored. This procedure features the employment of silanes as commercially available materials.

Journal: :Chemistry 2015
Peter W Moore Paul M Mirzayans Craig M Williams

A non-hygroscopic tetraphenylborate salt of N-methylmorpholine-N-oxide (NMO) is reported (NMO⋅TPB), which modulates the standard Ley-Griffith oxidation such that benzylic and allylic alcohols are oxidised selectively. An attractive feature of this new protocol is that anhydrous conditions are not required for this selective tetra-n-propylammonium perruthenate (TPAP) oxidation, superseding the r...

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