Transporters are major determinants of the disposition of xenobiotics and endogenous chemicals in the body. Organic anion transporter 3 (Oat3) functions in the kidney and brain to remove metabolic waste, toxins, and drugs, and thus transports diverse chemicals. Some b-lactam antibiotics interact with Oat3, and penicillin G exhibits a strong dependence on Oat3 for renal elimination. However, ove...

Dissimilar diffusion bonds of TiAl alloy to AISI 310 stainless steel using Ni/Ti reactive multilayers were studied in this investigation. The Ni and Ti alternating layers were deposited by d.c. magnetron sputtering onto the base materials, with a bilayer thickness of 30 and 60 nm. Joining experiments were performed at 700 and 800 ̋C for 60 min under pressures of 50 and 10 MPa. The effectiveness...

Abstract. Temperature reduction of superplastic forming titanium alloys is currently a significant issue. The present study focused on the effect modifying Ti-4Al-3Mo-1V-0.1B alloy with 0.5-2 wt% Co additions behavior and microstructure evolution. results demonstrated that alloying promoted formation recrystallized globular before beginning deformation due to acceleration diffusivity by in comp...

We propose a new concept to improve functional/mechanical properties of Fe-high Mn alloys, by suppressing thermal γ → ε martensitic transformation with proper thermo-mechanical treatment. As an experimental example demonstrate the validity this concept, we tried shape memory effect Fe-15.3Mn-5.8Si-0.24C (mass-%) alloy hot rolling. The showed dual γ/ε phase at room temperature (Ms = 66°C) and po...

Abstract The effect of the carbon content (0-2 at.%) on structure and mechanical properties at room cryogenic temperatures CoCrFeNiMn-based high entropy alloys with reduced Cr concentration was studied. as-cast were cold rolled to a thickness reduction 80% annealed 800°C for 1 hour. As result, fully recrystallized microstructure grain size 6.4 ?m produced in carbon-free alloy. much smaller (1.5...

Investigations of the plastic deformation mechanisms Ni-W-based heavy alloys varying with increasing temperatures are very important for development hot forming processes and applications at elevated temperatures. In this study, continuous variation strength plasticity a novel alloy was investigated. The tensile Ni48W35Co17 sample 600 °C 471 MPa, which 47% lower than that 100 °C. A in an abnorm...

The effects of the modification a high-?' Ni-8.5Cr-5.5Al-1Ti (wt.%) model superalloy with 0.5 wt.% Y2O3, manufactured by laser powder-bed fusion, on microstructure and compressive creep resistance were investigated. Compared to base alloy, oxide-dispersion strengthened (ODS) alloy exhibits 8-10 times slower rates at 800 °C, over wide range stresses (35-250 MPa). Two regimes observed: diffusiona...

The surface electrocatalytic reactivity of noble metals, for instance Pt, has frequently been modified by alloying Pt with less noble metal atoms within the top surface and/or subsurface layer.1,2 Monolayers of pure Pt deposited on top of non-Pt substrates also showed significantly altered surface catalytic reactivity.3 Here, we report a distinctly different synthetic strategy to modify the sur...

Compound casting refers to a process that used to produce bimetals. This study investigates the interface of Mo40/C93200 that is produced by compound casting process. In this research, molten bronze is poured around steel core, interaction between liquid and solid creates a diffusion zone and followed by a transition layer which leads to the creation of diffused region between the interfaces of...