THE PHYSIOLOGICAL AND PHARMACOLOGICAL SOCIETIES in the UK have been aware for some time that statistical testing and data presentation in our journals can fall short of the high standards that we wish to maintain. Over recent years other medical and life science journals have made substantial efforts to address similar problems. For example, the BMJ set out to improve reporting in medical journ...

Why do people sometimes seem to know things but fail to act appropriately on the basis of this knowledge? Such dissociations between knowledge and action often occur in infants and children, and in adults following brain damage. These dissociations have supported inferences about the organization of cognitive processes (e.g., separable knowledge and action systems) and their development (e.g., ...

CSCW systems have generally failed to meet the requirements of users in actual cooperative work settings, primarily due to constraints imposed by current platform architectures that do not adequately support the fluent transitions between formal and informal interaction or the inextricable interweaving of individual and cooperative work that characterizes everyday work practice. Based on a soci...

Sequential activation of neurons that occurs during "offline" states, such as sleep or awake rest, is correlated with neural sequences recorded during preceding exploration phases. This so-called reactivation, or replay, has been observed in a number of different brain regions such as the striatum, prefrontal cortex, primary visual cortex and, most prominently, the hippocampus. Reactivation lar...

A publisher’s customer and user data typically comes in many forms and from many specialized repositories and systems. For sales and marketing staff in particular, there is considerable insight to be gained from analysing all of this data closely. However, achieving an integrated and complete ‘single customer view’ via a data warehouse solution can be a costly, time-consuming and challenging un...

INTRODUCTION Long term potentiation (LTP) is defined as a long-lasting enhancement in communication between two neurons after the delivery of high frequency trains of electrical stimulation. This adjustment in synaptic efficacy is the physiological process that sustains learning and memory. However, few studies have addressed the existence of a similar phenomenon in the human cortex, even thoug...

Cardiovascular disease (eg, myocardial infarction, ischemic stroke) is the leading cause of death in patients who have metabolic syndrome and diabetes mellitus. By effectively treating the whole patient, however, the risk of death from cardiovascular disease can be reduced or prevented. The author describes clinical approaches for achieving this goal. He reviews information that is useful to kn...

record of the course of molecular dynamics in a single measurement would be invaluable. In this context, the article by Poulin and Nelson represents a valuable advance. The authors show how one can obtain— in a single shot—time-sequenced transient absorption spectra of irreversible chemical reactions that are initiated with a laser in a solid sample. To do so they use echelons, which are window...

Ubiquitous computing technologies offer the promise of extending the benefits of computing to workers who do not spend their time at a desktop environment. In this paper, we review the results of an extended study of nonoffice workers across a variety of work domains, noting some key characteristics of their practices and environments, and examining some challenges to delivering on the ubicomp ...

While virtual humans are proven tools for training, education and research, they are far from realizing their full potential. Advances are needed in individual capabilities, such as character animation and speech synthesis, but perhaps more importantly, fundamental questions remain as to how best to integrate these capabilities into a single framework that allows us to efficiently create charac...