BACKGROUND Müllerian aplasia (MA) is a congenital disorder of the female reproductive tract with absence of uterus and vagina with paramount impact on a woman's life. Despite intense research, no major genes have been found to explain the complex genetic etiology. METHODS AND RESULTS We have used several genetic methods to study 112 patients with MA. aCGH identified CNVs in 8/50 patients (16%...

Abstract The Ruby Mountains–East Humboldt Range–Wood Hills–Pequop Mountains (REWP) metamorphic core complex, northeast Nevada, exposes a record of Mesozoic contraction and Cenozoic extension in the hinterland North American Cordillera. timing, magnitude, style crustal thickening succeeding thinning have long been debated. Pequop Mountains, comprising Neoproterozoic through Triassic strata, are ...

The Erongo subvolcanic center in Namibia is the largest composite, bimodal complex in the Mesozoic Etendeka igneous province of Namibia. This study of 40Ar/39Ar and high spatial resolution U^Pb zircon dating demonstrates that emplacement of the various igneous units at Erongo took place within a time span equivalent to or shorter than geochronologically resolvable age differences (ca. 2 Ma), an...

1 Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA 2 Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA 3 Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA 4 Duke University Medical Center, Durham, NC, USA 5 Division of Cardiology, Department of Medicine, North...

The age of breakup which formed the Central-North Atlantic has been debated for many decades and is still subject to debate: from ca. 150 Ma 110 Ma. To address this issue, we have carried out a thermochronological study eastern margin rifted Iberia-Newfoundland sector. New apatite fission-track (AFT) data acquired on samples footwall (Variscan basement) one sample (Triassic Lusitanian Basin) ha...

1 Department of Civil and Environmental Engineering, University of California, Irvine, Irvine, CA, USA, 2 Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA, 3 Department of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA, 4 Bermuda Institute of Ocean Sciences, St. George’s, Bermuda, 5 Ecosystems Center, Marine Biological Laborat...

1 SA MRC Centre for TB Research, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, 8000 2 Department of Ecology and Evolution, Stony Brook University, Stony Brook, NY 11794 3 Analytic and Translational Genetics Unit, Department of Medicine, Massachusett...