Iron-catalyzed carbonylation reactions are highly desirable in our sustainability-advocating chemical community because of its low cost, abundance, and potential for distinct complementary reactivity patterns. Meanwhile, alkyl bromides as well nucleophilic amides indoles considered to be particularly challenge substrates reactions. Herein, we report an iron-catalyzed carbonylative coupling unac...

Abstract Proteolysis‐targeting chimeras (PROTACs) have recently emerged as powerful molecules for targeted protein degradation. As such, synthetic methods their modular synthesis are of prime importance in medicinal chemistry. We report the development both batch and flow photoredox methodologies C sp 3 −C 2 cross‐electrophile couplings alkyl bromides with E3 ligase‐binding aryl (thalidomide le...

Abstract: Neurotoxic organotin reagents currently play a key role in radical chemistry. As a result, this is an important area for development of new clean replacement reactions. The pharmaceutical industry in particular has had to avoid use of radical methodology for the formation of carbon–carbon bonds for this reason. With the current dawn in green chemistry, a host of new clean radical meth...

The synthesis of some novel alkyl/aryl substituted tertiary alcohols was accomplished in two steps. The synthetic route involves preparation of Grignard reagents by treating alkyl/aryl bromides with magnesium turnings in dry ether. Then substituted chalcones were reacted with the Grignard reagents to afford alkyl/aryl substituted tertiary alcohols 1-10. The structures of the synthesized compoun...