To the Editor: Alfentanil is a new narcotic capable of blunting intraoperalive haemodynamic responses while allowing for return of spontaneous ventilation and consciousness after short surgical procedures. We have recently noted reports of severe bradycardia with the use of alfentanil combined with succinylcholine, t,2 We also present such a case. A 76-year-old 45 kg woman was scheduled for rem...

to compare intubating conditions and hemodynamic changes between bonfils intubation fiberscope and macintosh laryngoscopy without administering neuromuscular blocking drugs (nmbds). methods: in this randomized controlled trial,80 male and female patients, scheduled for elective surgery, aged 15 to 60 years, asa class ii or i, non-obese, non smokers, without anticipated difficult intubation; wer...

Evidence suggests both opioid mu and delta receptors may participate in the regulation of respiration at different central nervous system sites. In the past, the overlapping receptor specificity of various opioid drugs has made it difficult to dissect the receptor subtype-specific activities involved in respiratory regulation. The new family of delta receptor selective agents such as cyclic[D-P...

BACKGROUND In open TCI and anaesthesia display systems, the choice of pharmacokinetic (PK) parameter sets of opioids is clinically relevant. Accuracy and bias of the PK models may be affected by administration mode and the co-administered hypnotic drug. We retrospectively evaluated the performance of eight PK parameter sets for alfentanil in two data sets (infusion and bolus application). MET...