An important part of pathogenesis of Alzheimer's disease (AD) is attributed to the contribution of AGE (Advanced Glycation Endproducts) and ALE (Advanced Lipid peroxidation Endproducts). In order to attenuate the progression of AD, we designed a new type of molecules that consist of two trapping parts for reactive carbonyl species (RCS) and reactive oxygen species (ROS), precursors of AGE and A...

To evaluate and develop methodologies for the extraction of gel-forming extracellular polymeric substances (EPS), EPS from aerobic granular sludge (AGS) was extracted using six different methods (centrifugation, sonication, ethylenediaminetetraacetic acid (EDTA), formamide with sodium hydroxide (NaOH), formaldehyde with NaOH and sodium carbonate (Na2CO3) with heat and constant mixing). AGS was ...

A great deal of research exists on the neural basis of theory-of-mind (ToM) or mentalizing. Qualitative reviews on this topic have identified a mentalizing network composed of the medial prefrontal cortex, posterior cingulate/precuneus, and bilateral temporal parietal junction. These conclusions, however, are not based on a quantitative and systematic approach. The current review presents a qua...

We propose the speech noise reduction system based on the frequency domain adaptive line enhancer. The adaptive line enhancer (ALE) is effective to extract sinusoidal signals blurred by a broadband noise. The ALE utilizes only one microphone; therefore, it is suitable for miniaturizing portable electronic devices. Especially, our proposed system adopts the frequency domain adaptive filter by us...

Arbitrary Lagrangian Eulerian (ALE) methods have existed for several decades. However, three-dimensional multi-material arbitrary Lagrangian Eulerian (MMALE) methods for unstructured grids are relatively new. MMALE algorithms provide the framework to model sections of a simulation as either Lagrangian, ALE, or Eulerian. In addition, sections of a simulation can switch in time between mesh motio...

This paper presents the design and evaluation of the hardware circuit for electronic stethoscopes with heart sound cancellation capabilities using field programmable gate arrays (FPGAs). The adaptive line enhancer (ALE) was adopted as the filtering methodology to reduce heart sound attributes from the breath sounds obtained via the electronic stethoscope pickup. FPGAs were utilized to implement...

One of the steps in the Arbitrary Lagrangian Eulerian (ALE) algorithm is the improvement of the quality of the computational mesh. This step, commonly referred to as rezoning, is essential for maintaining a mesh that does not become invalid during a simulation. In this paper, we present a new robust and computationally efficient 2D mesh relaxation method. This feasible set method is a geometric...

Adaptive Learning Environments (ALE) in Higher Education aim to provide academics with flexible learning tools that fulfil the needs of a heterogeneous learning community. ALE can be used to enhance traditional teaching as well as web-based instruction and can promote the implementation of alternative, open modes of learning and instruction. The utilisation of ALE in the educational process req...

Reactive carbonyl compounds are formed during autoxidation of carbohydrates and peroxidation of lipids. These compounds are intermediates in the formation of advanced glycation end products (AGE) and advanced lipoxidation end products (ALE) in tissue proteins during aging and in chronic disease. We studied the reaction of carbonyl compounds glyoxal (GO) and glycolaldehyde (GLA) with pyridoxamin...

Nootropic effect of alcoholic (ALE; 50, 75, 100 mg/kg) and aqueous (AQE; 100, 200, 400 mg/kg) extracts of P. tuberosa was evaluated by using Elevated Plus Maze (EPM), scopolamine-induced amnesia (SIA), diazepam-induced amnesia (DIA), clonidine-induced (NA-mediated) hypothermia (CIH), lithium-induced (5-HT mediated) head twitches (LIH) and haloperidol-induced (DA- mediated) catalepsy (HIC) model...