Cellular utilization of RNA interference (RNAi) as a mechanism to combat virus infection is thought to be restricted to plants and invertebrates. In vertebrates, antiviral defenses are largely dependent on interferons (IFNs), with the use of small RNAs restricted to microRNA (miRNA)-mediated targeting of host transcripts. Here we demonstrate that incorporation of a primary miRNA into a cytoplas...

Block-structured AMR meshes are often used in astrophysical fluid simulations, where the geometry of the domain is simple. We consider potential efficiency gains for time sub-cycling, or time refinement (TR), on Berger-Collela and oct-tree AMR meshes for explicit or local physics (such as explict hydrodynamics), where the work per block is roughly constant with level of refinement. We note that...

We investigate the international propagation of tax rate shocks originating in USA using a global vector error correction model. identify to corporate and personal income rates by narrative series as external instruments, following proxy-SVAR methodology. The main results are following: (1) In terms fiscal multiplier, domestic effects stronger than those shock; (2) spillovers most cases positiv...

Let $M_R$ be a module with $S=End(M_R)$. We call a submodule $K$ of $M_R$ annihilator-small if $K+T=M$, $T$ a submodule of $M_R$, implies that $ell_S(T)=0$, where $ell_S$ indicates the left annihilator of $T$ over $S$. The sum $A_R(M)$ of all such submodules of $M_R$ contains the Jacobson radical $Rad(M)$ and the left singular submodule $Z_S(M)$. If $M_R$ is cyclic, then $A_R(M)$ is the unique ...

In the face of Covid-19 pandemic, where death, sickness and suffering persist, there is some hint that nothing so special about human race particularly makes it immune to decimation. This at odds with general feeling something significant, purposeful and/or meaningful life. Thus, question immediately comes mind whether present pandemic negative situations presents, destroy any hope attaining me...

The CJEU judgment in the two latest Islamic headscarf cases was handed down July 2021. allows employers to ban wearing of religious and other symbols by employees, but it does specify under what conditions this can be done. This article builds on a previous opinion AG Rantos Shadow Opinion former Sharpston analyses detail. It argues that is an improvement judgments provides more protection for ...

efforts to achieve effective and meaningful patient and public involvement (ppi) in healthcare have existed for nearly a century, albeit with limited success. this brief commentary discusses a recent paper by carter and martin exploring the “challenges facing healthwatch, a new consumer champion in england,” and places these challenges in the context of the broader struggle to give a voice to h...

We used commonality analysis to explore the unique and overlapping contributions of two closely related executive functions, working memory sustained attention, prediction children’s reading achievement, over above age verbal IQ. Children aged 8–10 years (N = 104) completed measures capacity, attention IQ achievement (operationalised as word comprehension). found that capacity explained relativ...

This article hypothesizes that maternal occupation-specific skills are associated with children’s cognitive development over and above parents’ other human, financial social capital. Data from the UK Millennium Cohort Study on 13,543 children were complemented occupation-level data (n = 79) British Skills Surveys aggregate measures of mothers’ (literacy, numeracy, problem-solving, verbal physic...

Focal plane X-ray polarimetry is intended for relatively bright sources with a negligible impact of background. However this might not be always possible IXPE (Imaging Polarimetry Explorer) when observing faint extended like supernova remnants. We present the first time expected background by Monte Carlo simulation and its on real observations point sources. The has been performed based GEANT4 ...