M. Væth, and N. Obel. What is the problem and what is known about it so far? Human immunodeficiency virus is the cause of AIDS, an illness that interferes with the body’s ability to fight infection and some types of cancer. Human immunodeficiency virus passes from person to person through contact with blood or other body fluids that contain the virus. Treatments containing multiple drugs have d...

Dysfunction of the central nervous system (CNS) is a prominent feature of the acquired immune deficiency syndrome (AIDS). Many of these patients have a subacute encephalitis consistent with a viral infection of the CNS. We studied the brains of 12 AIDS patients using in situ hybridization to identify human immunodeficiency virus [HIV, referred to by others as human T-cell lymphotropic virus typ...

Using mathematical models that show the host-pathogen interaction of the immune system with the HIV virus, this paper identifies the extent to which the stages in the progression of HIV/AIDS are controllable, given that the available treatment strategies are constrained. These constraints are the imperfect inhibition of the replication of the virus by the available drugs, undesirable side effec...

Infeksi Human Immunodeficiency Virus (HIV) salah satu penyakit menular yang dapat mempengaruhi kematian ibu dan anak, penyebab dari tingginya kasus ini dipengaruhi oleh pengetahuan mengenai pencegahan penularan HIV ke anak (PPIA) masih kurang. Tujuan pengabdian masyarakat agar orang dengan HIV/AIDS (ODHIV) pada Ibu hamil perempuan usia reproduksi memiliki baik, terutama dalam mencegah terjadiny...

Rhesus monkeys (Macaca mulatta) were experimentally infected with strains of simian immunodeficiency virus (SIV) derived from SIVmac239 lacking vpr, vpx, or both vpr and vpx genes. These auxiliary genes are not required for virus replication in cultured cells but are consistently conserved within the SIVmac/human immunodeficiency virus type 2/SIVsm group of primate lentiviruses. All four rhesus...

The recent discovery of long term AIDS nonprogressors who harbor nef-attenuated HIV suggests that a naturally occurring live vaccine for AIDS may already exist. Animal models have shown that a live vaccine for AIDS, attenuated in nef, is the best candidate vaccine. There are considerable risks, real and perceived, with the use of live HIV vaccines. We have introduced a conditional lethal geneti...

BACKGROUND Malaria and AIDS represent 2 leading causes of death from infectious diseases worldwide, and their high geographic overlap means coinfection is prevalent. It remains unknown whether distinct immune responses during coinfection with malaria and human immunodeficiency virus (HIV) affect clinical outcomes. METHODS We tested this hypothesis by employing macaque models of coinfection wi...