نتایج جستجو برای: agonist 5
تعداد نتایج: 1253596 فیلتر نتایج به سال:
N-methyl-d-aspartate (NMDA) receptors are ligand-gated ion channels assembled from GluN1 and GluN2 subunits. We used a series of N-hydroxypyrazole-5-glycine (NHP5G) partial agonists at the GluN2 glutamate binding site as tools to study activation of GluN1/GluN2A and GluN1/GluN2D NMDA receptor subtypes. Using two-electrode voltage-clamp electrophysiology, fast-application patch-clamp, and single...
Abstract 4-{2-[(2-hydroxybenzyl)amino]ethyl}-2,5-dimethoxybenzonitrile (25CN-NBOH) was first reported as a potent and highly selective serotonin 2A receptor (5-HT2AR) agonist in 2014. The compound has since found extensive use pharmacological tool variety of vivo vitro studies. In the present study, we an improved scalable synthesis 25CN-NBOH making this readily available to scientific communi...
BACKGROUND AND PURPOSE 5-HT3 receptors are composed of 5-HT3A subunits (homomeric receptors), or combinations of 5-HT3A and other 5-HT3 receptor subunits (heteromeric receptors, the best studied of which are 5-HT3AB receptors). Here we explore the effects of partial agonists at 5-HT3A and 5-HT3AB receptors, and the importance of a channel-lining residue in determining the efficacy of activation...
Electrochemical methods were used to explore the exocytotic nature of serotonin (5-HT) release in human carcinoid BON cells, an vitro enterochromaffin cell model, understand mechanisms operating gut-derived 5-HT intestinal mucosal epithelium. We show that fractional vesicular cells is 80 % compared previous work pancreatic beta (34 %). The increased from control 87 with preincubation and nearly...
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