OBJECTIVE To compare the effects of aggressive tight control therapy and conventional care on radiographic progression and disease activity in patients with early mild inflammatory arthritis. METHODS Patients with two to five swollen joints, Sharp-van der Heijde radiographic score (SHS) <5 and symptom duration ≤2 years were randomized between two strategies. Patients with a definite non-RA di...

Obesity is an epidemic in the US and an established risk factor for breast cancer incidence and morbidity. In obese patients breast cancer is commonly more aggressive and associated with poor prognosis. The goal of our research is to develop safe and efficient novel therapies to treat aggressive breast tumors, like those in obese patients. To enhance drug uptake we intend to develop electro-end...

Most prostate cancers (PCas) are classified as acinar type (conventional) adenocarcinoma which are composed of tumor cells with luminal differentiation including the expression of androgen receptor (AR) and prostate-specific antigen (PSA). There are also scattered neuroendocrine (NE) cells in every case of adenocarcinoma. The NE cells are quiesecent, do not express AR or PSA, and their function...

PURPOSE Aggressive periodontitis, especially in its severe form, was traditionally considered to have an unfavourable prognosis. It required a complex treatment and its stabilization was often achieved by surgical therapy. The aim of this study was to investigate the results of nonsurgical periodontal treatment in severe generalized forms of aggressive periodontitis. METHODS Patients with adv...

A trial was initiated to determine the feasibility and efficacy of a three-phase treatment including: (1) induction chemotherapy (IC); (2) high-dose melphalan with total body irradiation supported by unpurged autologous bone marrow transplantation (ABMT); and (3) interferon (IFN) alpha maintenance treatment, in previously untreated aggressive myeloma. Thirty-five consecutive patients, ages unde...

o bjectives: the aim of this study was to determine the cementum thickness in the first molars of patients with localized aggressive periodontitis (lap) compared to healthy individuals. materials and methods: this case-control study compared eight first molar teeth af-fected by lap with eight third molar teeth of healthy individuals. the teeth were dis- infected by immersion in 10% buffered for...

Contrarily to SARS and MERS, the evidence suggests that thromboembolic events are common in patients with COVID-19 pneumonia. The clinical course of severe can be complicated coagulopathy, causing fatal requiring adequate treatment anticoagulant therapy. However, clinicians should alerted about increase bleeding related aggressive anticoagulation protocols, especially critically ill who undergo...

Septic bacterial arthritis is an orthopaedic emergency, requiring aggressive management. It is characterised by joint pain, swelling and weakness. Untreated, the condition has significant mortality and morbidity [1]. Delayed treatment leads to increased likelihood of systemic and local sequelae; cartilage can be destroyed within days [2]. Treatment is by urgent and aggressive joint washout, deb...

Although there are a variety of tools and modalities for diagnosing treating malaria, it is still regarded as one the most common diseases with high mortality morbidity1. Different unusual presentations can be seen in form ARDS, myocarditis, hemophagocytosis2, suspicion should raised to prompt early aggressive antimalarial therapy reduce complications.

Intracranial atherosclerosis accounts for 5 to 10% of all strokes. The natural history is poor, especially among patients with a greater than 70% stenosis. Studies of medical therapy have shown no benefit to warfarin over aspirin in these patients. In fact, patients with a greater than 70% stenosis who present with a stroke in the territory at risk have a 25% risk of stroke in the subsequent 24...