Periodontal diseases are essentially infectious in origin, their outcome depending on interaction between the pathogenic challenge and host response. Nevertheless the presence of an underlying genetic predisposition cannot be overlooked. HLA antigens have been considered as risk factors for periodontitis. The aim of the present study was to investigate the HLA-A*9 and HLA-A*10 association with ...

Background and aims. It has been reported that Type I hypersensitivity plays an important role in periodontal diseases. The aim of this study was to investigate the possible correlation between interleukin-1β, IL-6, and tumor necrosis factor-α as immunologic mediators and gingival clinical parameters in chronic and aggressive periodontitis. Materials and methods. Clinical parameters including c...

papillon-Lefèvre Syndrome (PLS) Is A Very Rare Autosomal Recessive Disorder Characterized By Palmoplantar Hyperkeratosis And Severe Early Onset Of Destructive Periodontitis Leading To Premature Loss Of Both Primary And Permanent Dentitions. Here We Are Presenting Case Report Of Siblings Who Presented With Palmoplantar Hyperkeratosis And Aggressive Periodontitis.

OBJECTIVE The aim of this study was to determine the impact of the polymorphisms at position -607 (C/A) and -137 (G/C) in the promoter of the IL-18 gene and their haplotypes, on the individual susceptibility of developing Aggressive (AgP) and/or Chronic (CP) periodontitis. MATERIALS AND METHODS A total of 213 unrelated Italian subjects with periodontitis (AgP=109 and CP=104) and 100 periodont...

Myeloperoxidase (MPO) is a lysosomal enzyme found in the azurophilic granules of polymorphonuclear leukocytes. It is involved in the defense against periodontal bacteria, and is also able to mediate inflammatory tissue destruction in aggressive and chronic periodontitis. The aim of this study was to explore the association between MPO-463G/A gene polymorphism and aggressive periodontitis (AgP) ...

BACKGROUND Loss of bone and soft tissue attachment are common sequelae of periodontitis that may jeopardize the aesthetic outcome and compromise the functional and aesthetic outcomes of treatment. The following case report describes one of the most predictable techniques of vertical ridge augmentation, which is orthodontic extrusion or forced eruption of hopeless teeth. METHOD A 34-year-old w...

Received: 25 June 2008 Accepted: 19 November 2008 Abstract: Objective: Recent studies have demonstrated that various human viruses, especially cytomegalovirus (HCMV) and Epstein Barr virus (EBV-1) seem to play a part in the pathogenesis of human periodontitis. The aim of this investigation was to evaluate the subgingival presence of HCMV and EBV in patients with aggressive periodontitis (AgP). ...

Periodontitis is characterized by the loss of the supporting tissues of the teeth in an inflammatory-infectious context. The diagnosis relies on clinical and X-ray examination. Unfortunately, clinical signs of tissue destruction occur late in the disease progression. Therefore, it is mandatory to identify reliable biomarkers to facilitate a better and earlier management of this disease. To this...

The aim of the present study was to determine the prevalence of localized and generalized aggressive periodontitis, as well as of incidental attachment loss, in a population of adolescents and young adults aging between 15 and 25 years (19.4 +/- 3.44) from Vale do Paraíba - SP, who searched for general dental care at the Department of Dentistry, University of Taubaté, São Paulo. Six hundred pat...

Objective: The aim of this study was to investigate links among cytokine genetic variants and generalized aggressive periodontitis (GAgP). Methods: Thirty-five patients with generalized aggressive periodontitis and 85 healthy controls without periodontitis were included in the study. Probing depth (PD), clinical attachment loss (CAL), plaque index (PI), and gingival index (GI) were recorded as ...