Brachydactyly is a common feature of pseudohypoparathyroidism (PHP) type Ia. We studied the longitudinal growth of the short bones in the hand of a 15-yr-old girl with PHP type Ia who had been followed for congenital hypothyroidism. Radiographs of the hand of the patient, who had been X-rayed every year since 2 yr of age, were studied. She showed cone-shaped epiphyses of the hand at 2 yr of age...

One experimental approach to studying the effects of aging on physiological functional capacity in humans is to analyze the peak exercise performance of highly trained athletes with increasing age. To gain insight into the relationships among age, gender, and exercise task duration with use of this model, we performed a 5-yr (1991-1995) retrospective analysis of top freestyle performance times ...

UNLABELLED Myocardial perfusion reserve (hyperemic divided by basal myocardial blood flow) describes vasodilator responsiveness of coronary-resistive vessels. The effect of aging and gender on myocardial perfusion reserve remains controversial. METHODS We studied 56 normal volunteers (21 women, 35 men; aged 50 +/- 20 yr, range 21-86 yr) with 15O-water PET to measure myocardial blood flow duri...

Allergic heredity plays a major role in the development of allergic rhinitis. In addition the introduction of food may influence the risk of subsequent allergic disease. The aim of this study was to analyse early risk factors and protective factors for allergic rhinitis at preschool age. Data were obtained from a prospective, longitudinal study of a cohort of children born in the region of west...

OBJECTIVE To consider the relevance of the duration of a clinical trial in ankylosing spondylitis: long-term (i.e. 1 yr) vs short-term (i.e. 6 weeks) assessment of a non-steroidal anti-inflammatory drug (NSAID)-placebo controlled study. METHODS The design was a prospective, multicentre, double-blind, placebo-controlled study of 6 weeks duration with a 12 months double-blind extension. Study d...

There is a high need for novel treatment options in relapsed and refractory diffuse large B-cell lymphoma. Single agent mammalian target of rapamycin (mTOR) inhibitor has shown promising efficacy this entity. Here, we report on the results mTOR-inhibitor temsirolimus combined to standard rituximab-DHAP salvage regimen prospective, multicenter, phase II, open-label study. The STORM consisted rit...

Belief propagation is a message-passing algorithm for performing inference in graphical models that has been implemented in a variety of domains including artificial intelligence, information theory and statistical physics. As we know, BP provides exact results only on a relatively restrictive subclass of problems, when the graphical model is a tree (or more generally if each connected componen...

Exact identification of an insect sample is usually the first essential step in a forensic entomological analysis. However, the morphological similarity of beetles in the level of species usually poses a challenge for forensic scientists within their routine work. As a supplementary to traditional morphological method, molecular genetics identification turns out to be simple and time-saving. A ...

CASE REPORT A 53-yr-old female presented with a 1-month history of cough productive of blood-flecked white sputum and right-sided chest pain. She had undergone a mastectomy 11 months previously for breast cancer. At surgery, the resection margins were free of tumour, lymph node sampling was negative, and no additional therapy was given. A chest radiograph at that time was normal. The patient’s ...