Background: Atrazine (ATR), an herbicide, is used in order to control broadleaf and grassy weed. ATR has been estimated to impact the testicular tissue both by inhibiting the endocrine system and partly by reducing the antioxidant status. Thus, current study was designed to evaluate the protective effect of vitamin E and testosterone against ATR-induced damages in testicular tissue. Materials a...

In this paper we present the convenient syntheses of seven new phenyl hydrazin derivatives 8 (a-h). For this purpose, acenaphtho [1,2-e]-1,2,4-triazine-9(8H)-thione (3) was prepared, starting from acenaphthylene-1, 2-dione (1) and thiosemicabazide in good yield. The reaction of (3) with benzyl chloride resulted to synthesis of 9-(benzylthio)-acenaphtho[1,2-e]-1,2,4-triazines (5) that reacted wi...

The in vitro antibacterial activity of ginger (Zingiber officinale) essential oil (GEO) was tested against five Gram-negative and Gram-positive fish pathgenic bacteria isolated from farmed olive flounder (Paralichthys olivaceus) in Korea. According to the results of disk diffusion, minimum inhibitory and minimum bactericidal concentration (MIC and MBC) tests, GEO was active against most of the ...

a new group of 4-(imidazolylmethyl) quinoline derivatives possessing a methylsulfonyl cox-2 pharmacophore at the para position of the c-2 phenyl ring were designed and synthesized as selective cox-2 inhibitors and in-vitro anti breast cancer agents. in-vitro cox-1 and cox-2 inhibition studies showed that all the compounds were potent and selective inhibitors of the cox-2 isozyme with ic50 value...

screening of microorganisms for the production of novel antibiotics has been intensivelypursued for many years by scientists. actinomycetes have the capability to synthesize manydifferent antibiotics. a total of 69 actinomycete isolates were recovered from soil samplescollected from alborz province. selected colonies (rough, chalky) of actinomycetes werepurified. all screened isolates were iden...

immunoglobulin e is one of the five classes of immonoglobulins that plays an important role in allergic diseases. production of monoclonal antibodies by a single clonotype against different epitopes of immunoglobulin e has high priority in development of diagnostic kits. in this study, an attempt was made to produce monoclonal antibodies against human immunoglobulin e. balb/c mice were immunize...

background: enterohemorrhagic escherichia coli (ehec) o157:h7 is an infectious zoonotic pathogen causing human infections. these infections, in some cases, can lead to hemolytic uremic syndrome and its life-threatening complications and even death worldwide. the first intimate bacterial adhesion, intimin (i), with its own receptor translocated intimin receptor (tir) and e. coli secreted protein...

Screening of microorganisms for the production of novel antibiotics has been intensivelypursued for many years by scientists. Actinomycetes have the capability to synthesize manydifferent antibiotics. A total of 69 actinomycete isolates were recovered from soil samplescollected from Alborz Province. Selected colonies (rough, chalky) of actinomycetes werepurified. All screened isolates were iden...

Food poisoning has been emerged as a worldwide health issue and related illness in both developed and developing countries confirms its significance as an important public health priority.In vitro antibacterialevaluationof nine fluoroquinolone derivatives against food borne bacteria including Gram-positive (Staphylococcus aureus) and Gram-negative (Salmonella enterica, Escherichia coli, Yersini...