نتایج جستجو برای: adult t cell leukemialymphoma
تعداد نتایج: 2405312 فیلتر نتایج به سال:
در این بررسی که طی سال های 1388 تا 1389 انجام گرفت، در مجموع هفت گونه و یازده جنس از پنج خانواده جمع آوری شدند که در بین آن ها، چهار جنس برای اولین بار از ایران و چهار گونه برای اولین بار از دنیا گزارش می شوند که به ترتیب با علامت های * و ** مشخص گردیده اند. لازم به ذکر است که بالاخانواده ی برای اولین بار از خاورمیانه گزارش می شود. اسامی گونه ها به ترتیب زیرگروه ها، بالاخانواده ها calyptosto...
In this issue of ONCOLOGY, Tobinai reviews the management of human T-cell lymphotropic virus type 1 (HTLV-1)–associated adult T-cell leukemia/lymphoma (ATL). Although rare in the United States, an estimated 10 to 20 million people are infected with HTLV-1 worldwide and 2% to 5% will develop ATL.[1] The prevalence of HTLV-1 infection and the consequent poor prognosis of ATL mark the disease as a...
Adult T-cell leukemia-lymphoma (ATL) is an uncommon highly aggressive T-cell lymphoma associated with human T-cell lymphotropic virus type 1 (HTLV-1) infection. It is rarely encountered during pregnancy and is particularly challenging to treat due to its aggressive nature and because of the lack of robust data on optimal chemotherapy. We report a case of a Jamaican immigrant diagnosed with ATL ...
Allelotype analysis of adult T-cell leukemia (ATL) was undertaken for the first time to identify chromosomal loci relevant to the development of acute/lymphomatous ATL. Loss of heterozygosity (LOH) was screened using 94 highly polymorphic microsatellite markers, distributed among all nonacrocentric, autosomal chromosomes. In each of the 22 cases, DNA obtained from their leukemic cells in acute/...
Pathogenesis of the disease: ATLL is associated with HTLV-1 infection of the tumour clone in 100% of the cases. The interval between HTLV-1 infection and the onset of lymphoma is long (10-40 years) and only <5% of infected people actually develops the disease. HTLV-1 produces a trans-regulatory protein (Tax) inducing interleukin-2 (IL-2) and IL-2 receptor expression and consequent polyclonal CD...
The molecular hallmarks of adult T cell leukemia (ATL) comprise outstanding deregulations of signaling pathways that control the cell cycle, resistance to apoptosis, and proliferation of leukemic cells, all of which have been identified by early excellent studies. Nevertheless, we are now confronted the therapeutic difficulties of ATL that is a most aggressive T cell leukemia/lymphoma. Using ne...
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