Tropheryma whipplei, which causes Whipple disease, has been detected in 4% of fecal samples from the general adult population of France. To identify T. whipplei within families, we conducted serologic and molecular studies, including genotyping, on saliva, feces, and serum from 74 relatives of 13 patients with classic Whipple disease, 5 with localized chronic T. whipplei infection, and 3 carrie...

The epidemiology of tuberculosis (TB) in the United States is changing as the incidence of disease becomes more concentrated in foreign-born persons. Mycobacterium bovis appears to be contributing substantially to the TB incidence in some binational communities with ties to Mexico. We conducted a retrospective analysis of TB case surveillance data from the San Diego, California, region from 199...

Background: APOE genotype provides information on risk of developing Alzheimer’s disease (AD), but disclosure is discouraged. We examined the impact of APOE disclosure in a prospective randomized controlled trial: the Risk Evaluation and Education for Alzheimer’s Disease (REVEAL) Study. Methods: We randomly assigned 162 asymptomatic adult children of AD patients to Genotype Disclosure (GD) or G...

This study examined the utility of word recognition scores for estimating actual Verbal IQ scores obtained from 1-5 years earlier. Participants were 271 persons remaining normal and 24 initially normal persons who developed cognitive impairment over longitudinal follow-up. A previously published regression equation based on education and the American modification of the National Adult Reading T...

B etween 1960 and 1994, the population of those 85 years and older in the United States grew 274%. Similarly, the fastest-growing sector of surgical patients older than 65 years is those older than 85 years. These figures are critical because elderly persons have the highest mortality in the adult surgical population (5.8%-6.2% in those 80 years in 500 consecutive patients requiring general or ...

The Pathways Into Homelessness project in Toronto interviewed 300 unaccompanied adult users of homeless shelters to identify characteristics of individuals who are homeless for the first time. The sample reflected the total population of homeless shelter users in terms of age, sex, level of use, and type of shelter. Two fifths of the sample were homeless for the first time. There were more simi...

Non-Hispanic Asian adults constituted 4.9% of the U.S. population in 2012, corresponding to 15.4 million people (2). This group primarily comprises persons of Chinese, Asian Indian, Korean, Filipino, Vietnamese, and Japanese descent. The prevalence of hypertension (defined as having blood pressure greater than or equal to 140/90 mm Hg or taking blood pressure-lowering medications) among non-His...

Goals of universal "test and treat" will never be fully realized if testing acceptance remains low, including rural areas, where HIV is increasingly recognized. We surveyed 250 randomly selected households from a rural Ethiopian town (Arba Minch) and surrounding villages about HIV testing experience, knowledge, and attitudes. Of the 558 adults, 45% were never HIV tested. Those never tested for ...

The Memory Magic concept (copyrighted, patent pending) is an innovative, engaging group activity for up to 20 persons with cognitive disabilities in both institutional and home care settings. A single activity staffer can run the activity leaving other staff to complete other tasks. The game may also be used for those with dementia, head trauma or intellectual disabilities at home. One hundred ...