BACKGROUND Despite the promising benefits of adaptive designs (ADs), their routine use, especially in confirmatory trials, is lagging behind the prominence given to them in the statistical literature. Much of the previous research to understand barriers and potential facilitators to the use of ADs has been driven from a pharmaceutical drug development perspective, with little focus on trials in...

PURPOSE American television viewers see as many as 16 hours of prescription drug advertisements (ads) each year, yet no research has examined how television ads attempt to influence consumers. This information is important, because ads may not meet their educational potential, possibly prompting consumers to request prescriptions that are clinically inappropriate or more expensive than equally ...

Researchers are rapidly developing new automated techniques to scale political speech on an ideological dimension. Yet, the task has proven difficult across many settings. Political advertisements, in particular, have eluded such efforts. Candidates air relatively few ads, containing limited policy information, and there is little agreement about how to model political speech in the campaign, m...

This study investigates if consumers can extract any meaning from ads that receive only a cursory and coarse glance, which is common in ad practice, and whether companies’ investments in all ads that receive such a glance are completely wasted. We find that typical ads communicate their gist better and faster than atypical ads under these conditions, and that they capture immediate interest. In...

Although anxiety disorders (ADs) have been recognized as one of the most prevalent mental disorders in mainland China, the prevalence of ADs has not been reported until now. The lack of a consolidated and comparable review on the prevalence of ADs in mainland China necessitated this meta-analysis to measure the prevalence. To identify the relevant studies on ADs for the analysis, we searched pu...

Click logs provide valuable information that can be used to infer several parameters related to the relevance of search results and ads to queries. However often there are much fewer clicks on ads as compared to search results. Thus while the click logs can easily be used to study parameters related to search results the sparseness of the number of clicks for ads renders it infeasible to infer ...

Anxiety disorders (ADs) are common mental disorders caused by a combination of genetic and environmental factors. Since ADs are highly comorbid with each other, partially due to shared genetic basis, studying AD phenotypes in a coordinated manner may be a powerful strategy for identifying potential genetic loci for ADs. To detect these loci, we performed genome-wide association studies (GWAS) o...

The problem of the quantum modes of the scalar free field on anti-de Sitter backgrounds with an arbitrary number of space dimensions is considered. It is shown that this problem can be solved by using the same quantum numbers as those of the nonrelativistic oscillator and two parameters which give the energy quanta and respectively the ground state energy. This last one is known to be just the ...