Objectives: This study was performed to assess the effects of α1A adrenoceptor antagonists on urethral perfusion pressure (UPP) and their therapeutic potential for female bladder outlet obstruction (BOO). Methods: A cannula was inserted into the femoral arteries of female rats to administer tamsulosin (treatment I), doxazosin (treatment II) or phentolamin (treatment III) and to monitor systemic...

Objective: We recently reported the hyper-responsiveness of human skeletal muscle resistance arteries (SkMRAs) to noradrenaline in critical limb ischaemia (CLI). In this study we investigated the characteristics of a -adrenoceptor subtypes and evaluated the agonist 1 affinity and adrenoceptor reserve in the ischaemic arteries. Methods: Human SkMRAs were isolated from non-ischaemic and ischaemic...

Receptors for sphingosine-1-phosphate (S1P) have been identified only recently. Their medicinal chemistry is therefore still in its infancy, and few selective agonists or antagonists are available. Furthermore, the selectivity of S1P receptor agonists or antagonists is not well established. JTE-013 and BML-241 (also known as CAY10444), used extensively as specific S1P(2) and S1P(3) receptors an...

The involvement of supraspinal alpha-adrenergic receptors in tonic pain was assessed in formalin-induced pain in rats. The alpha2 adrenoceptor agonist clonidine, along with yohimbine and prazosin, α2 and α1 receptor antagonists, were introduced intracerebroventrically (icv) and/or systemically in different doses. The data show that 1) clonidine exerts an alpha adrenergic analgesic effect, ...

The effect of some serotonin receptor antagonists was investigated on the body temperature of male mice. These antagonists produced significant reductions of body temperature in methamphetamine-induced hyperthermic male mice. Thus, the hyperthermia induced by methamphetaminc (11 ~tmol/kg,i.p.) was antagonized by the previous i.p. administration of 1.06 gmol/kg NAN-190 (5-HTIA receptor antagonis...