The effects of beta-adrenergic receptor stimulants (nylidrin and isoprotere-nol) on the hemorrhagic shock state of anesthetized dogs were measured and compared to those of phenoxybenzamine to determine the therapeutic effectiveness of the combined cardiac stimulatory and peripheral vasodilatory actions of the former drugs. Anesthetized dogs were subjected to 3 hours of hypo-volemia followed by ...

The role of Ca2+ in the adrenergic stimulation of pinealocyte cAMP and cGMP was investigated. In this tissue alpha 1-adrenoceptor activation, which by itself is without effect, potentiates beta 1-adrenergic stimulation of cAMP and cGMP 30- to 100-fold. The present results indicate that chelation of extracellular Ca2+ with EGTA or inhibition of Ca2+ influx with inorganic Ca2+ channel blockers (L...

MacGowan, Guy A., Jennifer Rager, Sanjeev G. Shroff, and Michael A. Mathier. In vivo -adrenergic responses and troponin I phosphorylation: anesthesia interactions. J Appl Physiol 98: 1163– 1170, 2005. First published December 3, 2004; doi:10.1152/japplphysiol.00959.2004.—The mechanisms by which -adrenergic stimulation of the heart in vivo can cause contractile dysfunction are not well understoo...

The importance of vital organ perfusion in patients suffering cardiac arrest makes arterial vasomotor tone, and the resultant perfusion pressure, critical in resuscitation from sudden death. Although there are multiple mechanisms that may affect arterial vascular tone, historically, the therapy most commonly used has been catecholamine-induced adrenergic receptor stimulation, with catecholamine...

The stability of the catechol-specific fl-adrenergic receptor of turkey erythrocytes was tested with certain physical and chemical agents. The receptor for the catechol function was stable at high temperatures or to treatment with ultrasound. Phospholipase, Pronase, trypsin, Triton X-100, sodium lauryl sulfate, or Lubrol-PX destroyed the catecholamine-sensitive adenylate cyclase but not catecho...