Not the Same Populations! When one compares the published meta-analysis of modern day induction and adjuvant chemotherapy trials, similar hazard ratios of just above 0.80 are seen with both strategies.[1,2] It is probably dangerous to conclude that these approaches have a similar efficacy, however, as the populations studied in induction trials are different from those in adjuvant studies. The ...

Analysis of data from patients treated outside clinical trials suggests that adjuvant chemotherapy for stage II colon cancer provides less than a 3% absolute improvement in survival at 5 years. This is remarkably close to the small degree of benefit suggested by controlled studies. An overview of the data suggests that surgery alone cures approximately 75% of stage II patients. Between 20% and ...

meeting on 21-02-2014. Adjuvant chemotherapy Introduction: evolution in adjuvant chemotherapy regimens Adjuvant chemotherapy improves outcome for women with high-risk breast tumours. The first issue is how to select women for adjuvant (or neoadjuvant) chemotherapy. This topic is beyond the scope of the present manuscript, but several guidelines are available.1 Breast cancer biological subtype, ...

BACKGROUND The results of the recently published large European randomised study in rectal cancer (European Organisation for Research and Treatment of Cancer 22921 trial) do not support current guidelines recommending postoperative chemotherapy for patients who have previously undergone preoperative radiochemotherapy or radiotherapy [radio(chemo)therapy]. To evaluate this discrepancy further, a...

PURPOSE The main objective of the present study was to evaluate the efficacy and toxicity of concurrent chemoradiotherapy followed by adjuvant chemotherapy compared with concurrent chemoradiotherapy alone in the treatment of locoregionally advanced nasopharyngeal carcinoma. METHODS The search strategy included Pubmed, Embase, the Cochrane Library, China National Knowledge Internet Web, Chines...

OBJECTIVE The aim of this study is to identify the prognostic significance of X-ray cross-complementing gene 1 (XRCC1) in patients with gastric cancer undergoing surgery and platinum-based adjuvant chemotherapy. METHODS Immunohistochemistry (IHC) was used to evaluate XRCC1 protein expression profiles on surgical specimens of 612 gastric cancer patients. The relationship between XRCC1 expressi...