Cell wall proteins with sialidase activity are involved in carbohydrate assimilation, adhesion to mucosal surfaces, and biofilm formation. Gardnerella spp. inhabit the human vaginal microbiome encode up three enzymes, two of which suspected be cell associated. Here, we demonstrate that gene encoding extracellular NanH3 is found almost exclusively piotii closely related species genome sp. 3, its...

Cytoskeletal remodeling affects the shape, adhesion, and motility of cells. dynamics are modulated by matrix proteins, integrins, several cytokines in tumor microenvironment. In this scenario, signaling is activated integrins interferons, which can induce ISG15 gene expression. This encodes a ubiquitin-like protein that functions as modifier via ISGylation system. Furthermore, non-conjugated ac...

T HE multistep theory of tumorigenesis is now widely accepted. During the tumor development the genetic alterations are accumulated, oncogenes are activated, and tumor suppressor genes are inactivated. Recently, the interesting idea is emerging that some cell adhesion molecules, integral membrane proteins, may work as tumor suppressors (Hedrick et al., 1993). Most of these cell adhesion molecul...

Synaptogenesis is thought to be mediated by cell adhesion proteins, which induce the initial contact between an axon and its target cell and subsequently recruit and organize the presynaptic and postsynaptic protein machinery required for synaptic transmission. A new study by Linhoff and colleagues in this issue of Neuron identifies adhesion proteins of the LRRTM family as novel synaptic organi...

Abstract Background The extracellular matrix (ECM) is a mosaic of various structural and functional proteins that cooperate with the cell, regulate adhesion, consequently manage its further fate. Liver destruction accompanied by disruption physicochemical properties ECM which deregulates cell–ECM interaction can lead to uncontrolled proliferation neoplastic transformation cells. Therefore, it b...

A unique characteristic of astrocytic malignancies is their frequent dissemination through the brain. Cellular determinants of migration include adhesion to the substratum, restructuring of the actin cytoskeleton to generate motion, and (in the setting of invasion into tissue) secretion of enzymes for remodeling interstitial space to accommodate forward motion of the migrating cell. In order to...

Microplasts are large extracellular vesicles originating from migratory, invasive, and metastatic cancer cells. Here, to gain insight into the role of microplasts in progression, we performed a proteomic transcriptomic characterization isolated MCF-7 breast cells treated with macrophage-conditioned medium. These were found be viable, highly metabolically active, indicating that derived these no...

Effector T cell migration into inflamed sites greatly exacerbates tissue destruction and disease severity in inflammatory diseases, including graft-versus-host disease (GVHD). T cell migration into such sites depends heavily on regulated adhesion and migration, but the signaling pathways that coordinate these functions downstream of chemokine receptors are largely unknown. Using conditional kno...

Golgi antiapoptotic proteins (GAAPs) are highly conserved Golgi membrane proteins that inhibit apoptosis and promote Ca(2+) release from intracellular stores. Given the role of Ca(2+) in controlling cell adhesion and motility, we hypothesized that human GAAP (hGAAP) might influence these events. In this paper, we present evidence that hGAAP increased cell adhesion, spreading, and migration in a...