نتایج جستجو برای: adenomatous polyposis coli

تعداد نتایج: 158575  

2007
Daan B. de Koning Joost P. H. Drenth Wim J. G. Oyen Michiel Wagenaar Riena P. Aliredjo Fokko M. Nagengast

We present a 53-year-old female suffering from familial adenomatous polyposis, who was found to have a positive nodus, lateral to the hilus of the left lung, on routine FDG-PET scan. This lesion was found to be a sclerosing hemangioma. We found an aberrant beta-catenin expression on immunohistochemical staining, suggesting that sclerosing hemangioma and familial adenomatous polyposis share the ...

2013
Andrzej Plawski Tomasz Banasiewicz Pawel Borun Lukasz Kubaszewski Piotr Krokowicz Marzena Skrzypczak-Zielinska Jan Lubinski

Familial adenomatous polyposis (FAP) is a well-defined autosomal dominant predisposition to the development of polyposis in the colon and rectum at unusually early ages. The first symptoms of FAP are diarrhea and blood in the stool. Weight loss and weaknesses occur after the development of advanced tumour. The incidence of the FAP disorder is one per 10000 newborns. There are high levels of het...

Journal: :The Journal of bone and joint surgery. British volume 1958
W P COCKSHOTT A OMOLOLU

2014
Vincent Cavaillès Marion Lapierre

Colon cancer frequently results from mutations that constitutively activate the Wnt signaling pathway, a major target being the tumor suppressor gene adenomatous polyposis coli (APC). We recently identified the transcription factor RIP140 as a new inducer of APC gene transcription that inhibits colon cancer cell growth and impedes the Wnt signaling pathway by reducing β-catenin activation.

Journal: :Cell 2014
Charlotte H. Coles Frank Bradke

Microtubule plus-end tracking proteins are crucial for the regulation of microtubule dynamics. Preitner et al. report that one such protein, adenomatous polyposis coli (APC), also binds RNA and identify mRNAs encoding tubulin subunits within the brain APC-RNA interactome, suggesting a new mode of microtubule self-regulation.

Journal: :گوارش 0
narimantas evaldassamalavicius

introduction: due to the whole network of polyposis registers worldwide and early prophylactic treatment, survival of familial adenomatosis (fap) patients is improved. extracolonic manifestations are remarkable feature of fap. two extracolonic manifestations (duodenal adenomatosis, leading duodenal cancer and desmoid tumours) play a very important role in the reasons of death in polyposis popul...

2009
Feride Aydin Claus Ferdinand Eisenberger Andreas Raffel Alexander Rehders Stefan Benedikt Hosch Wolfram Trudo Knoefel

Fistulae between an ileal pouch and the vagina are an uncommon complication of ileal pouch-anal anastomosis following proctocolectomy and mucosectomy in patients with familial adenomatous polyposis coli. Several reports describe the successful use of muscle flaps to close recurrent pouch-vaginal-fistulae (PVF). However, series only contain small numbers and an optimal management has not yet bee...

Journal: :Acta medica Okayama 1994
J A Perdomo H Iwagaki A Hizuta N Tanaka K Orita

Familial adenomatous polyposis (FAP) is a well-known autosomal dominant disorder characterized by the formation of multiple adenomatous polyps of the colon. Gardner's syndrome is a variant of familial polyposis coli, and both can be associated with colonic or extracolonic benign and/or malignant tumors. It has been widely recognized that an adenocarcinoma of the colon develops in virtually all ...

2015
Shan-Shan Jiang Jian-Jun Li Yin Li Long-Jun He Qi-Jing Wang De-Sheng Weng Ke Pan Qing Liu Jing-Jing Zhao Qiu-Zhong Pan Xiao-Fei Zhang Yan Tang Chang-Long Chen Hong-Xia Zhang Guo-Liang Xu Yi-Xin Zeng Jian-Chuan Xia

Familial adenomatous polyposis (FAP) is an autosomal dominant disease manifesting as colorectal cancer in middle-aged patients. Mutations of the adenomatous polyposis coli (APC) gene contribute to both FAP and sporadic or familial colorectal carcinogenesis. Here we describe the identification of the causative APC gene defects associated with FAP in a Chinese pedigree. All patients with FAP were...

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