This study describes our efforts to further the field of noninvasive diagnostics, specifically in the area of liquid biopsies in oncology. We employed laser scanning cytometry using highly selective antibodies to interrogate circulating tumor cells (CTCs) that were isolated using ApoStream(®) technology to identify folate receptor alpha (FRα)-positive cells. We demonstrate that FRα(+) CTCs can ...

Letrozole is a drug used in the treatment of postmenopausal women with breast and ovarian tumours. There is no evidence in the literature indicating its use in treating gastric cancer. We present a 68 year old lady admitted from the emergency department with weight loss, malaise and anaemia. Investigations confirmed the presence of two different primary tumours in the left breast and the stomac...

Abstract This review aimed to assess the antioxidant properties of safrole, myristicin, and terpineol from Myristica fragrans Houtt. Safrole exhibited high cytotoxic activities against numerous cancer cell lines also shown able suppress tumor angiogenesis. Myristicin is increase activity glutathione peroxidase (GPX), reductase (GR) or glutathione-disulfide-reductase (GSR), superoxide dismutase ...

background: we studied the patterns of premenopausal and postmenopausal breast cancer incidence and its established risk factors in iran in 2010. in addition, we estimated the 5-year prevalence of breast cancer in the country. methods: we performed an internet and library literature review. we used national cancer registry data, demographic health surveys, national censuses and world bank data ...

We present the case of a 32-year-old woman who, 10 months after abdominoperineal resection and total mesorectal excision for a locally advanced mucinous adenocarcinoma of the rectum, presented with local recurrence and metastases to the breast, spine, the left eye and orbit. Following surgery, due to the patient's personal reasons, adjuvant chemoradiation was not given. The patient died 2 month...

Further investigations on phytochemical constituents of dichloromethane extract fromroots of Salvia lachnocalyx (S. lachnocalyx) led to the isolation and identification of eightknown diterpenoids from this plant for the first time. The chemical structures of the purifiedcompounds were elucidated using spectroscopic analyses including EI-MS, 1H and 13C NMR andby compariso...

Mammary-like adenocarcinoma of the vulva associated to Paget's disease is exceedingly rare. So, it is very important to perform all the pathological and immunohistochemical investigations to achieve differential diagnosis from both a metastatic lesion from an orthotopic breast cancer and a vulvar adnexal tumor. This report describes a case of vulvar Paget's disease associated with underlying ma...

Signet ring adenocarcinoma of the breast with synchronous metastasis to the gastrointestinal (GI) tract is a rare occurrence, typically presenting with abdominal pain, dyspepsia, or GI bleed. We report a case of metastatic breast cancer presenting with a complaint of anemia. A further diagnostic evaluation revealed generalized lymphadenopathy, nodular thickening of the urinary bladder wall, bon...

breast cancer is the most common cancer occurring among women. the mortality rate of breast cancer can be reduced by regular breast cancer screening program. this study was carried out to identify the knowledge and practice of women about breast cancer screening in zahedan, southeast of iran. in this cross- sectional study, 384 women were selected as an improbability sample of women referring t...

INTRODUCTION Cases of esophageal metastasis of breast cancer are extremely rare. We present the case of a patient who developed recurrence as esophageal metastasis following treatment of bilateral breast cancer. Early-stage gastric cancer was also found coincidentally. CASE PRESENTATION An 86-year-old Japanese female patient with a history of bilateral breast cancer was found to have a gastri...