Carbohydrate fatty acid (CFA) esters especially rhamnopyranoside having both the hydrophilic and lipophilic nature showed broader applications including anticancer activities. It was reported that appropriate conformation is needed for better activities conformational distortion reduced antimicrobial functionality. In this context, two different series of benzyl ?-L-rhamnopyranosides, one with ...

A particulate preparation isolated from Escherichia coli B catalyzes the acylation of 1-acyl-an-glycerol j-phosphate (I-acyl-GP) with both oleoyl-CoA and pahnitoyl-CoA. The optimum conditions were determined for the acyl-CoA: I-acyl-GP acyltransferase. The acyltransferase is specific for the I-acyl-GP and does not acylate 2-acyl-sn-glycerol 3-phosphate (2-acyl-GP) under the conditions used. The...

We recently reported that glycolipid compositions of gadoid fish nerve tissues are unique in the abundance of 1) galactosyl diacylglycerol and its sulfate ester; 2) glucosyl ceramide; and 3) fatty acid ester of cerebroside (J. Lipid Res. 1992. 33: 1351-1359). The present paper reports the characterization of less polar glycolipids isolated from Alaskan pollack brain. Of twelve glycolipids purif...

Poly(ADP-ribose)polymerase-1 (PARP-1) is an important target for drug design for several therapeutic applications. 5-Aminoisoquinolin-1-one (5-AIQ) is a highly water-soluble lead compound; synthetic routes to 3-substituted analogues were explored. Tandem Hurtley coupling of β-diketones with 2-bromo-3-nitrobenzoic acid, retro-Claisen acyl cleavage and cyclisation gave the corresponding 3-substit...

A series of novel methyl (R)-N-benzoyl/dichloroacetyl-thiazolidine-4-carboxylates were designed by active substructure combination. The title compounds were synthesized using a one-pot route from l-cysteine methyl ester hydrochloride, acyl chloride, and ketones. All compounds were characterized by IR, ¹H NMR, 13C NMR, and HRMS. The structure of 4q was determined by X-ray crystallography. The bi...

The enzyme phospholipase A2 catalyzes the hydrolysis of the sn-2 acyl chain of phospholipids, forming fatty acids and lysophospholipids. The crystal structure of a triple mutant (K53,56,121M) of bovine pancreatic phospholipase A2 in which the lysine residues at positions 53, 56 and 121 are replaced recombinantly by methionines has been determined at atomic resolution (0.97 A). The crystal is mo...

Investigating the alkylation and acylation of N-acylthiazolidinethione, the desired α-alkylated products and C-acylated products are not obtained, but rather the S-alkylated products and O-acylated products are obtained. The possible mechanism proposed shows that the deprotonation agent and electrophilic species are responsible for the stability of enolates. The enolates derived from N-acylthia...

In the title compound, [CoCl(2)(C(13)H(9)Cl(2)N(3)O(2))(2)(C(12)H(8)N(2))]·CH(3)OH, the Co(II) atom is octahedrally coordinated by two N atoms from the pyridyl rings of the tridentate N'-(3,5-dichloro-2-hydroxy-benzyl-idene)pyridine-4-carbohydrazide (H(2)L) ligand, two N atoms from the 1,10-phenanthroline ligand and two chloride ions. The acyl-hydrazone groups are not involved into the coordina...

In response to the increasing social demand for clean and environmental friendly procedures, recent years have witnessed a dramatic growth in the search for selective chemical processes with 100% atom economy. Among them, the catalyzed coupling of aldehydes to the corresponding esters (Tishchenko reaction, Scheme 1) is key for the synthesis of these valuable chemicals. 1] This reaction and the ...

The title compound, C(19)H(14)O(4), was prepared by the reaction of 2-oxo-2H-chromene-3-acyl chloride with cinnamic alcohol. The whole mol-ecule is not planar, the dihedral angle between the planes of coumarin and benzene rings being 13.94 (4)°, but the plane of the coumarin ring and that of the ester group are almost coplanar, making a dihedral angle of 2.9 (1)°. In the crystal structure, weak...