objective: following traumatic brain injury, disruption of blood-brain-barrier and consequent brain edema are critical events which might lead to increasing intracranial pressure (icp), and nerve damage. the current study assessed the effects of aqueous date fruit extract (adfe) on the aforementioned parameters. materials and methods: in this experimental study, diffused traumatic brain injury ...

Traumatic brain injury (TBI) is described by a disruption in the normal function of the brain due to an injury following a trauma, which can potentially cause severe physical, cognitive, and emotional impairment. The use of human stem cells and self-assembling peptide scaffolds suggest huge potential for application in the treatment of TBI. In the present study, we surveyed the beneficial effec...

OBJECTIVE Clinical observations report excessive sleepiness immediately following traumatic brain injury (TBI); however, there is a lack of experimental evidence to support or refute the benefit of sleep following a brain injury. The aim of this study is to investigate acute post-traumatic sleep. METHODS Sham, mild or moderate diffuse TBI was induced by midline fluid percussion injury (mFPI) ...

BACKGROUND Nociceptive and neuropathic pain occurs as part of the disease process after traumatic brain injury (TBI) in humans. Central and peripheral inflammation, a major secondary injury process initiated by the traumatic brain injury event, has been implicated in the potentiation of peripheral nociceptive pain. We hypothesized that the inflammatory response to diffuse traumatic brain injury...

INTRODUCTION Traumatic brain injury is a form of acquired brain injury that results from sudden trauma to the head. Specifically, mild traumatic brain injury is a clinical diagnosis that can have significant effects on an individual's life, yet is difficult to identify through traditional imaging techniques. CASE PRESENTATION This is the case of a 68-year-old previously healthy African Americ...

there are only a few, non-evidence based, neuroprotective strategies for treatment and prevention of brain injuries after closed head trauma. to establish new therapy strategies, a novel animal model is needed. the aim of our investigation was to link standardized small animal models and actual patient medical care. data of experimental small animal studies often cannot be transferred to cns in...

INTRODUCTION Adrenal insufficiency (AI) has a great impact on the prognosis of patients with traumatic brain injury. There is a lack of consensus regarding the diagnostic criteria of AI. In these patients with acute stress we compared fasting cortisol, low and high dose cosyntropin stimulation tests to assess adrenal function in patients with moderate to severe traumatic brain injury. MATERIA...

introduction: this study was designed to investigate the effects of granulocyte colony-stimulating factor (g-csf) administration in rats for 6 weeks after traumatic brain injury (tbi). methods: adult male wistar rats (n = 30) were injured with controlled cortical impact device and divided into four groups. the treatment groups (n = 10 each) were injected subcutaneously with recombinant human g-...

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Using data from the Trauma Audit Research Network, we investigated the costs of acute care in patients > or = 18 years of age hospitalised for traumatic brain injury between January 2000 and December 2005 in England and Wales. Traumatic brain injury patients were defined and stratified using the Abbreviated Injury Scale. A total of 6484 traumatic brain injury patients were identified; 22.3% had...