Renal proximal tubular damage and repair are hallmarks of acute kidney injury. As glycogen synthase kinase-3β (GSK3β) is an important cellular regulator of survival and proliferation, we determined its role during injury and recovery of proximal tubules in a mercuric chloride-induced nephrotoxic model of acute kidney injury. Renal proximal tubule-specific GSK3β knockout mice exposed to mercuric...

I.1. Definition I.2. What Is the Incidence and Outcome of Renal Failure in ICU Patients? I.3. Do Creatinine-clearance Markers and Other Biomarkers Help Identify Early Acute Renal Injury? I.4. How Should We Assess Renal Perfusion in an ICU Patient? I.5. Can We Predict which ICU Patient Will Develop Acute Renal Failure? II. What Can We Do to Protect against Developing Acute Renal Failure during R...

Primary prevention of acute renal failure (ARF) refers to clinical strategies which reduce the occurrence of ARF in patients with or without underlying chronic renal disease who do not yet exhibit evidence of acute renal dysfunction or injury. The lack of sensitive measures of renal injury (biomarkers) as well as the difficulty in assessing renal function in a “non-steady state” condition has l...

Glycogen synthase kinase-3β (GSK3β) is a serine/threonine protein kinase that plays an important role in renal tubular injury and regeneration in acute kidney injury. However, its role in the development of renal fibrosis, often a long-term consequence of acute kidney injury, is unknown. Using a mouse model of renal fibrosis induced by ischemia-reperfusion injury, we demonstrate increased GSK3β...

Glycogen synthase kinase-3β (GSK3β) is a serine/threonine protein kinase that plays an important role in renal tubular injury and regeneration in acute kidney injury. However, its role in the development of renal fibrosis, often a long-term consequence of acute kidney injury, is unknown. Using amousemodel of renal fibrosis induced by ischemia-reperfusion injury, we demonstrate increased GSK3β e...

I.1. Definition I.2. What Is the Incidence and Outcome of Renal Failure in ICU Patients? I.3. Do Creatinine-clearance Markers and Other Biomarkers Help Identify Early Acute Renal Injury? I.4. How Should We Assess Renal Perfusion in an ICU Patient? I.5. Can We Predict which ICU Patient Will Develop Acute Renal Failure? II. What Can We Do to Protect against Developing Acute Renal Failure during R...

introduction: during hemorrhagic shock (hs), the kidneys are one of the primary target organs involved. oxidative stress is shown to be enhanced in different models of acute kidney injury (aki). remote ischemic preconditioning (rpc) by brief limb ischemia is considered to be a safe method to protect different organs from further damage. in this study, we investigated the effects of brief hind l...

Renal dysfunction and injury secondary to medications are common. Drug-related kidney injury can present as subtle damage or rapid progressive renal failure and is thought to be one of the major causes of renal failure. Most of the nephrotoxic medications involve directly or indirectly renal tubulointerstitial injury via immune process and lead to specific clinical findings, including microangi...

Acute renal failure (ARF) induces tubular hyperresponsiveness to TLR4 ligands, culminating in exaggerated renal cytokine/chemokine production. However, the fate of TLR4 protein during acute tubular injury remains unknown. The study sought new insights into this issue. Male CD-1 mice were subjected to 1) unilateral ischemia-reperfusion (I/R), 2) cisplatin (CP) nephrotoxicity, or 3) glycerol-indu...

Acute kidney injury is common in intensive care patients and continuous renal replacement therapy is the preferred treatment for this in most centres. Although these techniques have been adopted internationally, there remains significant variation with regard to their clinical application. This is particularly pertinent when one considers that the fundamental questions regarding any treatment, ...