Legal and medical practitioners need to remember that, with respect to drug analysis, there are two distinct disciplines in analytical toxicology concerned with human biological matrices, namely clinical and forensic toxicology. Both fields use similar analytical techniques designed to detect and quantify drugs, chemicals and poisons in fluids or tissues. In clinical toxicology, analytical resu...

Toxicology is the study of poisons and poisoning and has an ancient and venerable history. Although there have been numerous notorious poisonings throughout the ages and rather astute descriptions of toxic agents, the scientific study of toxicology did not commence until the 19th century. There was rapid development of analytical methods in the late 19th century and then an acceleration of both...

Acute, subacute, and chronic toxicity studies, carcinogenicity bioassays, and reproductive and genetic toxicology studies were performed with quinapril, an ACE inhibitor used in the treatment of hypertension. Acute toxicity is minimal in rodents, and repeated dosing elicits gastric irritation, juxtaglomerular apparatus (JGA) hypertrophy and hyperplasia and tubular degenerative changes in the ki...

Enzyme-linked immunosorbent assays (ELISAs) are important tools in aquatic toxicology and have become crucial in assessing exposure concentrations in the aquatic environment and acute physiological responses in exposed organisms. These assays utilize the inherent properties of antibodies to recognize and selectively bind a target molecule, while largely ignoring other molecules to provide semiq...

DEPARTMENT OF PESTICIDE REGULATION MEDICAL TOXICOLOGY BRANCH SUMMARY OF TOXICOLOGY DATA Fipronil Chemical Code # 3995, Tolerance # 52062 SB 950 # NA Original: April 26, 2005 Revised: December 12, 2006, July 16, 2010, 12/20/10, 3/25/11 I. DATA GAP STATUS Chronic toxicity, rat: No data gap, possible adverse effect indicated Chronic toxicity, dog: No data gap, possible adverse effect indicated Onc...

Journal of Veterinary Pharmacology and TherapeuticsVolume 46, Issue S1 p. 65-65 ORAL PRESENTATIONS O75 | Pharmacodynamic phenotypic evaluation eprinomectin resistant Haemonchus isolates from French dairy sheep farms First published: 11 June 2023 https://doi.org/10.1111/jvp.13241Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give access...

Journal of Veterinary Pharmacology and TherapeuticsVolume 46, Issue S1 p. 81-82 ORAL PRESENTATIONS O109 | Protective effects quercetin towards aflatoxin B1-induced hepatotoxicity in cattle: A whole transcriptomic vitro study First published: 11 June 2023 https://doi.org/10.1111/jvp.13275Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Gi...

Journal of Veterinary Pharmacology and TherapeuticsVolume 46, Issue S1 p. 41-41 ORAL PRESENTATIONS O27 | Flea resistance to fipronil: Confirmation metabolic detoxification through innovative HPLC dosage within fleas First published: 11 June 2023 https://doi.org/10.1111/jvp.13193Read the full textAboutPDF ToolsRequest permissionExport citationAdd favoritesTrack citation ShareShare Give accessSha...