BACKGROUND Nerve growth factor (NGF) has received much attention for its role in mood disorders. The primary objective of the present study was to examine serum NGF levels in Chinese inpatients with depressive or manic episodes in the acute phase and to explore the changes in NGF levels after effective clinical treatments. METHODS One hundred and seven consecutive inpatients and outpatients w...

OBJECTIVE The purpose of this study was to evaluate the effect of adjunctive topiramate in treating acute mania. METHODS In this study which was a double-blinded randomized clinical trial, 46 bipolar patients in manic episode, were treated with lithium carbonate and topiramate versus lithium carbonate and placebo and treatment responses were assessed by Young Mania Rating Scale (YMRS) weekly....

INTRODUCTION Aripiprazole is approved for the acute and maintenance treatment of manic and mixed episodes associated with bipolar I disorder. The aim of the present work was to review and meta-analyze the findings of all the available randomized double-blind controlled trials (RCTs) on the efficacy of aripiprazole in the treatment of bipolar disorder. MATERIAL AND METHODS Aripiprazole RCTs we...

Abstract Introduction While seen in patients with bipolar disorder due to NMS, antipsychotic side effects, or substance use, rhabdomyolysis resulting from behaviors mania has not been reported recent literature. We present a case of patient exertion during manic episode. Case A 29-year-old male history type 1 was brought the ED June 2022 after he found on roof local theater sharing excerpts boo...

OBJECTIVES To compare Cloninger's dimensions of temperament and character in patients with bipolar I disorder (BP-I) and healthy controls from the general population. MATERIALS AND METHODS This cross sectional study included 96 BP-I patients (according to DSM-IV-TR criteria) that were admitted to a psychiatric hospital in Iran due to an acute episode of mania or depression, or a mixed episode...

BACKGROUND Reports indicate that PDLIM5 is involved in mood disorders. The PDLIM5 (PDZ and LIM domain 5) gene has been genetically associated with mood disorders; it's expression is upregulated in the postmortem brains of patients with bipolar disorder and downregulated in the peripheral lymphocytes of patients with major depression. Acute and chronic methamphetamine (METH) administration may m...