background: wnt molecules play a key role in growth, proliferation and development of some embryonic and adult organs as well as hematopoietic stem cells. wnt signaling pathways are aberrantly activated in many tumor types, including solid tumors and hematologic malignancies. objective: to investigate the expression profile of a large number of wnt genes in leukemic cells from iranian patients ...

background evidence indicates rfc1 g80a polymorphism as a risk factor for a number of cancers. increasing studies have been conducted on the association of rfc1 g80a polymorphism with acute lymphoblastic leukemia (all) risk. however, the results were  controversial. the aim of the present study was to derive a more precise estimation of the relationship.  materials and method pubmed, embase, we...

objective: to classify different types of acute leukemia based on cooperative game theory and shapley value. materials and methods: in this study, patients data were collected from flow cytometry tests of the iran blood transfusion organization (ibto) have been used. 304 different diagnosed samples in 8 classes of acute leukemia were investigated. samples were initially in numerical format. i...

Background: Acute Myeloid Leukemia (AML) with translocation (3,3) is a form of AML that may present de novo or may arise from a previous myelodysplastic syndrome. It is often associated with normal or elevated peripheral blood platelet count and increased bone marrow megakaryocytes with associated multi lineage dysplasia. A subset of patients present with hepatosplenomegaly while a few cases h...

Introduction: Apoptosis is an important mechanism in both physiological and pathological conditions. The BCL2 family of proteins plays a critical role in regulation of apoptotic cell death. Up and down regulation of BCL2-like 12 (BCL2L12), a new member of the BCL2 family, has been reported in several malignancies. However, the expression level of BCL2L12 rarely has been studied in leukemia. T...

Nitric oxide (NO) is a molecule required for many physiological functions, produced from L-arginine by NO synthases (NOS). It is a free radical, producing many reactive intermediates that account for its bioactivity. Sustained induction of the inducible form of NOS (iNOS) in chronic inflammation may be mutagenic, through NO-mediated DNA damage or hindrance to DNA repair, and thus potentially ca...

given preliminary evidence of timed, sequential chemotherapy of high dose cytosine arabinoside the current study was initiated to assess the side effects and efficacy of this regimen in patients with newly acute myelocytic leukemia (aml). nineteen adults who referred to hematology-oncology and bone marrow transplantation (bmt) research center of tehran university of medical sciences were enroll...

background : acute myeloid leukemia (aml) is a disease in elderly patients, with a mean age of diagnosis of 70 years. we have analyzed the clinicopathology features and experimental variables in aml patients in eastern iran and the correlation between survival and fab subgroups of aml. materials and methods : during 2009 to 2014 in a retrospective study, 98 patients with aml referred to the cli...

introduction: fournier's gangrene or necrotizing fasciitis of external genitalia is a medical emergency. it was reported in cases of acute promyelocytic leukemia (apl) before and during induction therapy with all- trans retinoic acid (atra).we present a case of apl that developed fournier's gangrene   during atra therapy.