Seventy-six patients, aged 2 to 17 years, were treated with bone marrow transplantation for severe aplastic anaemia or acute leukaemia refractory to conventional therapy. 16 of the 22 patients (73%) who received marrow transplantations for aplastic anaemia are surviving, 12 of these for over one year. In acute leukaemia, using preparation with cyclophosphamide and total body irradiation, 8 of 3...

T HE results of treatment of forty-three patients with vira1 hepatitis by the Knott technic of bIood irradiation therapy are presented. Thirty-one cases of acute infectious hepatitis are incIuded in this series; three cases were chronic and of Iong standing, and tweIve were cases of acute serum hepatitis. These patients received no therapy other than the Knott technic of bIood irradiation. The ...

Tocols induce high levels of granulocyte-colony-stimulating factor (G-CSF). G-CSF mobilises progenitors that allow mice that have been severely immunocompromised by exposure to acute, high-dose ionising irradiation to recover and to survive. The neutralisation of G-CSF abrogates the radioprotective efficacy of tocols. This article reviews studies in which CD2F1 mice were irradiated with suffici...

We investigated the alterations of major fatty acid components in epidermis by natural aging and photoaging processes, and by acute ultraviolet (UV) irradiation in human skin. Interestingly, we found that 11,14,17-eicosatrienoic acid (ETA), which is one of the omega-3 polyunsaturated acids, was significantly increased in photoaged human epidermis in vivo and also in the acutely UV-irradiated hu...

Although rare, accidental irradiation overexposures remain difficult to treat, mainly because of a complex physiopathology, known as the acute radiation syndrome (ARS). As a consequence, the issue remains fatal for most of high dose radiation accident victims. This is due in part through the lack of biological indicators able to give information about the extent of radiation-induced damage. Suc...

Curcuma heyneana or temu giring is mainly popular for medicinal and beauty purposes; however due to its attractive inflorescence, it potential ornamental plant. This study aims describe morphological characteristics examine gamma irradiation effect on plant growth of C. heyneana. The method applied was acute irradiation, with 6 doses 0 Gy (control), 10 Gy, 20 30 40 50 Gy; 3 replications, 15 rhi...

Radiation-induced acute intestinal toxicity remains a major limitation to the delivery of tumoricidal doses of colorectal irradiation. Recent reports indicate that Toll-like receptor (TLR) agonists TLR4 and TLR5 protect against toxicity due to intestinal irradiation. The phenotype (M1 or M2) of macrophages expressing TLRs may play a role in tissue repair. The aim was to investigate whether admi...

The cause and progression of Alzheimer's disease (AD) are poorly understood. Possible cognitive and behavioral consequences induced by low-dose radiation are important because humans are exposed to ionizing radiation from various sources. Early transcriptional response in murine brain to low-dose X-rays (100 mGy) has been reported, suggesting alterations of molecular networks and pathways assoc...

Twenty-two patients with acute lymphoblastic leukemia in second or subsequent remission and 26 with acute lymphoblastic leukemia in relapse were given cyclophosphamide (60 mg/kg on each of 2 days), total body irradiation (920 rad), and marrow transplants from HLA-identical siblings. With a minimum follow-up of more than 5 yr, an actuarial analysis shows a survival and apparent cure of 27% of th...

New therapeutic strategies are needed to overcome drawbacks in treatment of infections with intracellular bacteria. Chlamydiaceae are Gram-negative bacteria implicated in acute and chronic diseases such as abortion in animals and trachoma in humans. Water-filtered infrared A (wIRA) is short wavelength infrared radiation with a spectrum ranging from 780 to 1400 nm. In clinical settings, wIRA alo...