Acute-on-chronic liver failure (ACLF) is a syndrome characterized by acute and severe decompensation of chronic disease (CLD) correlated with multiple organ failure, poor prognosis, increased mortality. In 40–50% ACLF cases, the trigger not recognized; for many these patients, bacterial translocation associated systemic inflammation thought to be determining factor; in other 50% sepsis, alcohol...

Hepatitis E virus (HEV) is one of the major causative agents of acute hepatitis in many developing countries. Recent intensive examination has revealed the existence of non-imported cases in industrialized countries. The patient was a 25-year-old Japanese female with acute hepatitis. Laboratory test demonstrated positive anti-nuclear antibody (ANA), anti-smooth muscle antibody (ASMA) and high l...

Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder of the mononuclear phagocytic system, characterised by histiocyte and lymphocyte activation. It can be classified as primary secondary HLH. Primary HLH usually presents in childhood, associated with gene mutations. Secondary adulthood, due to an underlying infection, autoimmune disease or malignancy. We describe case acute hepatitis-A ...

An enzyme-linked immunosorbent assay for the detection of immunoglobulin M (IgM) antibodies to hepatitis A virus is described. The test uses the principle of binding of IgM antibodies to anti-IgM-coated microtiter plates to determine whether the IgM antibodies attached have specificities for hepatitis A virus. In three patients with hepatitis type A followed up to 12 months, IgM antibodies to h...

OBJECTIVE To investigate the etiology of acute hepatitis in adult patients admitted in a hospital. METHODS The study included all acute hepatitis patients admitted in the Infectious Diseases Unit of Rashid Hospital Dubai (JCI accredited), UAE, from January 2006 to December 2007. Various viral markers were used to establish the diagnosis of acute hepatitis which included anti HAV IgM, HBsAg, A...

there is no report on the etiology of acute viral hepatitis in sistan and baluchestan province, southeast of iran. we performed this study to compare the clinical, biochemical and demographic properties of acute viral hepatitis (avh) in this province. demographic and clinical data were collected from 263 patients with avh. they were tested for hbsag, igm anti-hav, igm anti-hbc, igm anti-hdv, or...

The study of pattern of acute viral hepatitis (AVH) in children revealed that hepatitis A was most common in children (59.3%) followed by NANB hepatitis (29.7 %). A dual infection with hepatitis A and hepatitis B was present in 4.4% of cases. Hepatitis A was more commonly diagnosed in younger children (54.9%) while the frequency of NANB hepatitis increased with the advancing age. Liver function...

Sir, We read the article by Samanta et al. [1] on atypical manifestations of acute viral hepatitis A in children. This is not the first time that these atypical manifestations have been reported from India. Large studies [2, 3] of 172 and 149 cases each of sporadic acute viral hepatitis from two different institutions from north India have been published earlier. The study from Chandigarh has s...

Patients with COVID-19 may be asymptomatic or present extrarespiratory symptoms, such as liver injury. It has been reported that 22.5%–46.2% of patients have moderate elevation enzymes. To our knowledge, acute hepatitis never described an isolated symptom in a previously healthy patient. We report the case 53-year-old patient whose first clinical presentation was icteric hepatitis, several days...

Parvovirus B19 infection is usually self-limiting in immunocompetent individuals. Twenty-five percent of infected individuals are
 completely asymptomatic during infection, with 50% them presenting flu-like symptoms and the remaining patients presenting
 erythema infectiosum, arthralgia, or arthritis. More rarely, transient aplastic crisis seen chronic haemolytic
 disorders. Chro...