With the technical assistance of F. Schiffer, Dipl. Ing. A VARIABLE degree of blood destruction over and above that occurring physiologically is a constant phenomenon in attacks of malaria. Although blood destruction is always increased in a malarial attack, clinical signs of hemolysis ( jaundice, anemia, etc.) are not always present. The clinical syndrome of hemolytic anemia in malaria is know...

Haptoglobin, a conserved plasma glycoprotein, forms very stable soluble complexes with free plasma hemoglobin. Hemoglobin binding by haptoglobin is thought to be important in the rapid hepatic clearance of hemoglobin from the plasma and in the inhibition of glomerular filtration of hemoglobin. To evaluate these functions, Haptoglobin knockout (-/-) mice were created. These mice were viable but ...

       The oxidative hemolysis of rat erythrocytes induced by 2,2’-azobis–(2-amidinopropane) (AAPH) and its inhibition by rosemary essential oil was studied. Different concentrations (0.178, 0.357, 0.534 and 0.712 ml/ml) of the essential oil showed no significant hemolysis compared to phosphate buffer solution. AAPH (25 mM and 50 mM) induced hemolysis in a time-dependent manner. Diff e r e n t ...

Introduction: Extensive hemolysis resulting in anuric renal failure is the main clinical sign of acute arsine poisoning. Plasmapheresis and exchange transfusion are recommended for patients with massive hemolysis. We report four cases of arsine exposure which demonstrate the effectiveness of continuous vein-venous hemodiafiltration and on-line hemodiafiltration for arsenic removal. Method: Bloo...

By J. V. DAdE, M.B., M.R.C.P. LONDON H YDROGEN ion concentration has a controlling effect upon many hemolytic systems, both simple and complex. Osbor& in 1934 reviewed the early literature on the effect of pH on the hemolysis by complement of corpuscles sensitized by hemolytic immune body. He found that the optimum reaction for the hemolysis of sheep corpuscles by guinea pig serum was about pH ...

Many investigators have attempted to produce experimental acute renal failure by the administration of hemolyzed red blood cells or the products of hemolysis. Almost all of the successful attempts have required the preliminary preparation of the experimental animal by marked alteration of renal hemodynamics in association with systemic hypotension (1), severe dehydration (1, 2), or occlusion of...