There are only a few reports of the co-occurrence of acute poststreptococcal glomerulonephritis (APGN) and acute rheumatic fever. We report an unusual case of a 3-year-old boy with nephrotic syndrome and acute renal failure with the transitional need for peritoneal dialysis, biopsy-proven atypical IgA-dominant APGN, and concomitant acute rheumatic fever, successfully treated by steroids. Aggres...

IgA-dominant acute postinfectious glomerulonephritis (APIGN) is an increasingly recognized morphologic variant of APIGN, particularly in the elderly. In contrast to classic APIGN, in which there is typically glomerular deposition of IgG and C3 or C3 only, IgA is the sole or dominant immunoglobulin in IgA-dominant APIGN. Because the vast majority of reported cases occur in association with staph...

Glomerular infiltration by neutrophils is a hallmark of acute glomerulonephritis. The pathophysiological role of interleukin 8 (IL-8), a potent neutrophil chemotactic cytokine (chemokine), was explored in an animal model of acute immune complex-mediated glomerulonephritis by administering a neutralizing antibody against IL-8. Repeated injection of bovine serum albumin (BSA) into rabbits caused ...

Crescentic glomerulonephritis with immune complex deposition and acute eosinophilic interstitial nephritis developed in a patient with the hypereosinophilic syndrome. Acute renal failure ensued but was rapidly reversed by high-dose oral prednisone. Confounding factors and unusual findings are described with a review of recent literature. This mode of presentation has not previously been reported.

This paper describes the case of a 48 year old man who presented with acute hyperlipidaemia following pulmonary embolism. Subsequent investigation revealed that the hyperlipidaemia was secondary to nephrotic syndrome of glomerulonephritis. The case illustrates the importance of investigating acute hyperlipidaemia for its underlying causes.

Renal dysfunction associated with bacterial endocarditis can occur via a number of different mechanisms: immune complex deposition with glomerulonephritis, antibiotic-induced acute interstitial nephritis, acute tubular necrosis secondary to toxin or volume depletion, emboli causing renal infarction, direct invasion of the parenchyma by the microorganism, and thrombotic microangiopathy with cort...

While acute renal failure (ARF) due to leptospiral infection is on decline, malaria has become the emerging cause of ARF[1,2]. Acute renal failure is one of the important manifestations of severe falciparum (pf) malaria, although it can occur rarely with vivax (pv) also[3]. Recently high incidence of ARF has been reported from various parts of the world including India both in cases of falcipar...

Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer. ICIs a unique side effect profile, generally caused by inflammatory tissue damage, with clinical features similar to autoimmune conditions. Acute kidney injury from has been well studied; incidence ranges 1% 5%, higher when combination ICI therapies are used. Although overall reported ICI-associated glomerulonephri...

Acute glomerulonephritis is an uncommon disease in the middle-aged and elderly. Of the 173 cases investigated by Ellis (1942) only three were over 50 and none was over 60; and Fishberg (1954) reported only once seeing a patient older than 60. While acute glomerulonephritis may pursue a malignant course-with death from oliguric renal failure in the acute phase, at any age-older patients seem par...