We present a 55-year old male patient who was subjected to whole body skeletal scintigraphy for metastatic work up of urinary bladder cancer. Whole body 99mTc-methylene diphosphonate (MDP) skeletal scintigraphy was performed. That revealed no skeletal metastasis in the entire body skeleton and normally visualized left kidney with empty right renal fossa. Additionally tracer activity ...

Skeletal muscles play an active role in regulating the metabolic homeostasis through their ability for relating to adipose tissue and endocrine hormones. Contraction of the skeletal muscle leads to increased release of several myokines, such as irisin, which is able to interact with the adipose tissue. Physical activity promotes the irisin mechanism by augmenting the peroxisomes (PGC1-α) in the...

The antioxidant properties of coumarin derivatives using the 2,2ˈ -diphenyl-1- picrylhydrazyl (DPPH) radical scavenging assay were investigated by the application of Quantitative Structure Activity Relationship (QSAR) studies. The molecular structures were optimized and submitted for the generation of quantum chemical and molecular descriptors. Genetic Function Algorithm (GFA) was employed in m...

When I began studying biochemistry at the Graduate School of Pharmaceutical Sciences at the University of Tokyo, Japan, molecular cloning of retinoic acid receptors (RARs), the nuclear receptors for retinoids, was one of the hottest topics in medical science. In the laboratory of Professor Koichi Shudo, who was my mentor and now my current manager, the development of novel synthetic retinoids h...

In species with external fertilization, the guanylate cyclase family is responsible for the long-distance interaction between gametes, as its activation allows sperm chemotaxis toward egg-derived substances, gamete encounter, and fertilization. In species with internal fertilization, guanylate cyclase-activating substances, which are secreted by several tissues in the genital tracts of both sex...

ABSTRACI’ Thirty-one undergraduate men and women who weighed more (overweight) or who weighed less (underweight) than the normal weight limits for their height wore actometers on all four limbs 24 h each day for 14 consecutive days. All groups were found to be equally active. This result fails to replicate previously reported results that overweight men and women are hypoactive. This discrepanc...