AIMS This study aimed to investigate whether cabotegravir (CAB), an integrase inhibitor in development for treatment and prevention of human immunodeficiency virus-1, influences the pharmacokinetics (PK) of a levonorgestrel (LNG) and ethinyl oestradiol (EO)-containing oral contraceptive (OC) in healthy women. METHODS In this open-label, fixed-sequence crossover study, healthy female subjects ...

The cab genes which encode the light-harvesting chlorophyll a/b-protein (LHCP) are expressed normally with respect to phytochrome regulation in the hy-3 and hy-5 long hypocotyl mutants of Arabidopsis thaliana. In etiolated seedlings of these mutants as well as of the wild type, 1 min of red light elevates cab mRNA levels substantially within 2 h; this increase is reversed if far-red light is gi...

CONTEXT The current survey study investigated the recurrence rate of hyperprolactinemia after cabergoline (CAB)-induced pregnancy and after lactation as well as safety of CAB exposure during early gestation. PATIENTS AND METHODS From 1997-2008, 143 pregnancies were recorded in 91 patients with hyperprolactinemia (age 30.4 ± 4.7 yr, 76 microadenomas, 10 macroadenomas, and five nontumoral hyper...

Leaf area index (LAI) and leaf chlorophyll content (Cab) are two important indicators of vegetation growth. Due to the high-coupling spectral signals content, simultaneous retrieval LAI Cab from remotely sensed date is always challenging. In this paper, an approach for joint estimation grassland unmanned aerial vehicle (UAV) hyperspectral data was proposed. Firstly, based on a PROSAIL model, 15...

The UCF driving simulator was designed to be reconfigurable so that either a commercial truck cab or entire passenger vehicle (Saturn with engine and transmission removed) can be mounted on a motion platform. Several vehicle dynamics models are available for various truck/trailer combinations as well as different passenger vehicles. A study was performed to assess whether there are significant ...

Grapevine rootstocks play a pivotal role in plant responses to water deficiency (WD); therefore, the selection of new genotypes is promising strategy for future agricultural managements aimed cope with climate changes. Recent studies reinforced central root system modulating WD responses, as it not only controls uptake and transport leaves, but also participates stress perception signalling sho...

Abstract Background In a demonstration project, long-acting, injectable antiretroviral therapy (LA-ART) with cabotegravir-rilpivirine (CAB-RPV) achieved viral suppression in high proportion of people HIV (PWH) who were virologically non-suppressed due to adherence barriers. We projected the long-term impact CAB-RPV for PWH unable adhere oral ART. Methods Using CEPAC model, we compared three str...

6071 Background: Patients suffering from recurrent or metastatic (R/M) salivary duct carcinoma (SDC) are often treated with combined androgen blockade (CAB). This treatment however frequently fails (response rates: 18-53%), resulting in a worse prognosis. Therefore, biomarkers that have prognostic value and can predict response urgently needed. Methods: mRNA 77 R/M receptor (AR) positive SDC pa...

Youth participation in organized after-school activities provides opportunities for positive growth and development. Unfortunately, ethnic minority youth, especially those living in low-income communities, participate in these activities at lower rates and less consistently than nonminority youth. This article reviews the research on the academic, psychological, and behavioral outcomes of parti...

The eukaryotic green alga Dunaliella tertiolecta acclimates to decreased growth irradiance by increasing cellular levels of light-harvesting chlorophyll protein complex apoproteins associated with photosystem II (LHCIIs), whereas increased growth irradiance elicits the opposite response. Nuclear run-on transcription assays and measurements of cab mRNA stability established that light intensity-...