نتایج جستجو برای: activation receptor
تعداد نتایج: 919194 فیلتر نتایج به سال:
introduction: n-methyl-d-aspartate (nmda) receptors play a pivotal role in the development of tolerance and physical dependence to opiates. activation of nmda receptors involves the induction of long term potentiation (ltp) in hippocampus. our previous study suggested that chronic oral administration of morphine enhanced nmda dependent ltp in the ca1 area of hippocampal slices of rats. the pres...
Lysophosphatidic acid (LPA) and lysophosphatidylinositol bind to the G protein-coupled receptors (GPCRs) LPA GPR55, respectively. LPA2, a type 2 receptor, GPR55 are highly expressed in colon cancer involved progression. However, crosstalk between two potential effects on cellular physiology not fully understood. Here, using BRET analysis, we found that LPA2 interact live cells. In presence of b...
Introduction: Previous studies have shown that cannabinoidergic system is involved in anxiety. However, there are controversial reports in the experimental studies. The aim of this study is to evaluate the effect of pharmacological stimulation or blocking of CB1 receptors and inhibition of endocannabinoid degradation in anxiety like behavior in elevated plus-maze (EPM) test in rat. The EPM is o...
Abstract The introduction of the CTLA-4 recombinant fusion protein has demonstrated therapeutic effects by selectively modulating T-cell activation in rheumatoid arthritis. Here we show, using a forward genetic approach, that mutation SH3gl1 gene encoding endocytic Endophilin A2 is associated with development arthritis rodents. Defective expression affects T cell effector functions and alters t...
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