Protease-activated receptors (PARs) are seven-transmembrane G-protein coupled receptors activated by serine proteases (Fig. 1). Proteases cleave the extracellular Nterminus of the molecule to expose a new tethered ligand, which in turn binds and activates the cleaved receptor. Four PARs have been cloned and each has a unique cleavage site amino acid sequence. Tryspin activates PAR2 and PAR4. Th...

Stator flux oriented vector control of induction motor (IM) drives for speed sensorless control has several advantages. But the application of a pure integrator for the flux estimation is difficult due to the presence of measurement noise and dc offset. To overcome these problems, some have used a programmable cascaded low pass filter (PCLPF). In this paper, it is shown that some problems still...

Over the last ten years, robustness of schemes has raised an increasing interest among the CFD community. The objective of this article is to solve the quasi-one-dimensional compressible flow inside a “Shubin nozzle” and to investigate Bean-Warming and flux vector splitting methods for numerical solution of compressible flows. Two different conditions have been considered: first, there is a sup...

Axial field flux switching motor with sandwiched permanent magnet (AFFSSPM) is a novel of flux switching motor. Based on the vector control method, the mathematical model of the AFFSSPM is derived and the operating performance of the AFFSSPM in the overall operating region is investigated.A novel control method for the AFFSSPM drive system, including the id =0, maximum torque per ampere, consta...

T cells react to extremely small numbers of activating agonist peptides. Spatial organization of T-cell receptors (TCR) and their peptide-major histocompatibility complex (pMHC) ligands into microclusters is correlated with T-cell activation. Here we have designed an experimental strategy that enables control over the number of agonist peptides per TCR cluster, without altering the total number...