results in patients with high breast densities, malignant cases (61.2%) were significantly more in comparison to patients with low breast densities (37.3%) (p= 0.007, or=2.66 95% ci=1.29-5.49). after adjusting for age, density was associated with malignancy in age groups <46 years (p=0.007), and 46-60 years (p=0.024) but not in age group >60yrs (p=0.559). adjusting for menopausal status, densit...

Neurotensin receptors (nomenclature as recommended by NC-IUPHAR [39]) are activated the endogenous tridecapeptide neurotensin (pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu) derived from a precursor (NTS, 30990), which also generates neuromedin N, an agonist at NTS2 receptor. [3H]neurotensin (human, mouse, rat) and [125I]neurotensin may be used to label NTS1 0.1-0.3 3-5 nM concentrations...

Peroxisome Proliferator Activated Receptors Gamma (PPAR-ᵞ) is a nuclear transcription factor, which Protein receptors for insulin and have significant role in resistance Type 2 Diabetes mellitus addition to the of gene encoded differentiation Adipocyte development Adipose tissue. at present research has been detected substitution silent mutation C T exon 6 PPAR-ᵧ 111 women, including 73 obese w...

recent studies have shown that glucocorticoids may have modulatory effect on anxiety reactions. this effect may occur with opioid system interference. according to that, the purpose of this research is to assess the effect of dexamethasone as glucocorticoid agonist and its interaction with opioidergic system on the anxiety modulatory effect in plus maze model in mice. male white mice with mediu...

Phospholipase Cγ1 (PLCγl) and p21 guanosine triphosphatase (GTPase) activating protein (GAP) bind to and are phosphorylated by activated growth factor receptors. Both PLCγl and GAP contain two adjacent copies of the noncatalytic Src homology 2 (SH2) domain. The SH2 domains of PLCγl synthesized individually in bacteria formed high affinity complexes with the epidermal growth factor (EGF)or plate...

Traditionally, steroid receptors were believed to be activated only by ligand binding; however, recent studies indicate that steroid receptors can also be activated by mechanisms that do not require ligand, referred to as ligand-independent activation. Specifically, progestin receptors can be activated in vitro and in vivo after treatment with neurotransmitters, such as dopamine, in the absence...

Background. Itch can be transmitted by two parallel pathways, histaminergic and nonhistaminergic. Histaminergic itch is a subgroup of mechano-insensitive C-fibers, while nonhistaminergic polymodal C-fibers. Experimental models are used to study pruritus: histamine for the antagonizing H1-receptors, BAM8-22 cowhage activating Mas-related G protein-coupled receptors protease-activated receptors, ...

Several decades ago, fibrates were approved for the treatment of dyslipidemia, whereas thiazolidinediones were screened in animal models to improve glucose homeostasis and were subsequently developed for the treatment of type 2 diabetes mellitus. Relatively recently, these drugs were found to act via peroxisome proliferator-activated receptors, nuclear receptors that control lipid metabolism an...